دورية أكاديمية
Benefit/risk ratio profile of single inhaler triple therapy for сhronic obstructive pulmonary disease patients ; Профиль соотношения «польза / риск» для трехкомпонентной терапии единым ингалятором при лечении больных хронической обструктивной болезнью легких
| العنوان: | Benefit/risk ratio profile of single inhaler triple therapy for сhronic obstructive pulmonary disease patients ; Профиль соотношения «польза / риск» для трехкомпонентной терапии единым ингалятором при лечении больных хронической обструктивной болезнью легких |
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| المؤلفون: | Svetlana I. Ovcharenko, Andrey S. Belevskiy, С. И. Овчаренко, А. С. Белевский |
| المصدر: | PULMONOLOGIYA; Том 31, № 5 (2021); 645-652 ; Пульмонология; Том 31, № 5 (2021); 645-652 ; 2541-9617 ; 0869-0189 |
| بيانات النشر: | Pulmonology |
| سنة النشر: | 2021 |
| المجموعة: | Pulmonology (E-Journal) / Пульмонология |
| مصطلحات موضوعية: | единый ингалятор, long-acting β2-agonist, long-acting muscarinic antagonist, all-cause mortality, exacerbations, hospitalizations, triple therapy, single-inhaler triple therapy, обострения, госпитализации, ингаляционные глюкокортикостероиды, длительно действующие β2-агонисты, длительно действующие антихолинергические препараты, трехкомпонентная терапия |
| الوصف: | Chronic obstructive pulmonary disease (COPD) is associated with significant healthcare and socioeconomic burden. International guidelines recommend a personalized approach to treatment and management that aims to reduce symptom burden and exacerbation risk. Numerous recently published clinical trials have investigated efficacy and safety of single-inhaler triple therapy (SITT) with a long-acting muscarinic antagonist (LAMA), long-acting β2-agonist (LABA), and an inhaled corticosteroid (ICS) for patients with COPD.Aim of the publication: to review the findings of randomized controlled trials that showed the benefit of single-inhaler triple therapy and compare this benefit with the known risk of pneumonia associated with ICSs.Conclusion. The key benefits reported with SITT are significant reductions in exacerbations and hospitalizations; the trials also suggest reduced all-cause mortality. The benefits of SITT outweigh the known risk of pneumonia with ICS use that is reported as the class-effect in COPD patients. ; Хроническая обструктивная болезнь легких (ХОБЛ) характеризуется существенной нагрузкой на систему здравоохранения и значительным социально-экономическим бременем. Международные медицинские общества рекомендуют индивидуальный подход к лечению и ведению пациентов, направленный как на уменьшение выраженности симптомов, так и снижение риска обострений. За последние годы опубликованы многочисленные клинические исследования по изучению эффективности и безопасности назначения пациентам с ХОБЛ трехкомпонентной терапии с применением единого ингалятора (Single-Inhaler Triple Therapy – SITT), включающей в себя длительно действующий антихолинергический препарат, длительно действующий β2-агонист и ингаляционный глюкокортикостероид (иГКС).Целью данной публикации явился обзор рандомизированных контролируемых исследований, по данным которых продемонстрирована польза SITT, а также оценка этой пользы по сравнению с описанным риском развития пневмонии при применении иГКС.Заключение. Ключевыми преимуществами SITT является ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | Russian |
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| DOI: | 10.18093/0869-0189-2021-31-5-645-652 |
| الإتاحة: | https://doi.org/10.18093/0869-0189-2021-31-5-645-652Test https://doi.org/10.1186/1471-2458-11-612Test https://doi.org/10.2147/CEOR.S34321Test https://doi.org/10.1080/15412550500218221Test https://doi.org/10.1378/chest.121.5.1449Test https://doi.org/10.1378/chest.119.2.344Test https://doi.org/10.1080/14737167.2020.1678385Test https://doi.org/10.1055/s-0030-1254069Test https://doi.org/10.2147/COPD.S34186Test https://doi.org/10.2147/COPD.S139470Test |
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| رقم الانضمام: | edsbas.35B787CB |
| قاعدة البيانات: | BASE |
| DOI: | 10.18093/0869-0189-2021-31-5-645-652 |
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