دورية أكاديمية
Chemical Compositions of Lianqiao (
| العنوان: | Chemical Compositions of Lianqiao ( |
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| المؤلفون: | Gao, Boyan, Zhu, Hanshu, Liu, Zhihao, He, Xiaohua, Sun, Jianghao, Li, Yanfang, Wu, Xianli, Pehrsson, Pamela, Zhang, Yaqiong, Yao, Yuanhang, Yu, Liangli |
| المصدر: | Pharmaceuticals (Basel) ; ISSN:1424-8247 ; Volume:17 ; Issue:6 |
| بيانات النشر: | MDPI |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | ACE2, COVID-19, Forsythia suspensa (Lianqiao), HPLC-MS/MS, SARS-CoV-2 virus spike protein, radical scavenging |
| الوصف: | This study evaluated the fruits of Forsythia suspensa (Lianqiao), an important economic crop, for the chemical components of its water and ethanol extracts, inhibitory effects on SARS-CoV-2 virus spike protein binding to ACE2, inhibition of ACE2 activity, and capacity to scavenge free radicals. A total of 42 compounds were tentatively identified in the extracts via HPLC-MS/MS analysis. The water extract showed a greater ACE2 inhibition but a weaker inhibition on SARS-CoV-2 spike protein binding to ACE2 than the ethanol extract on a per-botanical-weight-concentration basis. The phenolic content was found to be greater in the water extract at 45.19 mg GAE/g dry botanical weight than in the ethanol extract (6.89 mg GAE/g dry botanical). Furthermore, the water extract had greater scavenging capacities against HO●, DPPH●, and ABTS●+ at 448.48, 66.36, and 121.29 µmol TE/g dry botanical, respectively, as compared to that of the ethanol extract (154.04, 3.55, and 33.83 µmol TE/g dry botanical, respectively). These results warrant further research into, and the development of, the potential COVID-19-preventive applications of Lianqiao and its extracts. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.3390/ph17060740Test; https://pubmed.ncbi.nlm.nih.gov/38931407Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206439Test/ |
| DOI: | 10.3390/ph17060740 |
| الإتاحة: | https://doi.org/10.3390/ph17060740Test https://pubmed.ncbi.nlm.nih.gov/38931407Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11206439Test/ |
| رقم الانضمام: | edsbas.BD0F5582 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/ph17060740 |
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