دورية أكاديمية
Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson's Disease.
| العنوان: | Positron Emission Tomography Imaging of Synaptic Dysfunction in Parkinson's Disease. |
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| المؤلفون: | Niu, Jiaqi, Zhong, Yan, Jin, Chentao, Cen, Peili, Wang, Jing, Cui, Chunyi, Xue, Le, Cui, Xingyue, Tian, Mei, Zhang, Hong |
| المصدر: | Neurosci Bull ; ISSN:1995-8218 ; Volume:40 ; Issue:6 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Alpha-synuclein, Dopamine system, Non-dopamine system, Parkinson’s disease, Positron emission tomography, Synapse dysfunction |
| الوصف: | Parkinson's disease (PD) is one of the most common neurodegenerative diseases with a complex pathogenesis. Aggregations formed by abnormal deposition of alpha-synuclein (αSyn) lead to synapse dysfunction of the dopamine and non-dopamine systems. The loss of dopaminergic neurons and concomitant alterations in non-dopaminergic function in PD constitute its primary pathological manifestation. Positron emission tomography (PET), as a representative molecular imaging technique, enables the non-invasive visualization, characterization, and quantification of biological processes at cellular and molecular levels. Imaging synaptic function with PET would provide insights into the mechanisms underlying PD and facilitate the optimization of clinical management. In this review, we focus on the synaptic dysfunction associated with the αSyn pathology of PD, summarize various related targets and radiopharmaceuticals, and discuss applications and perspectives of PET imaging of synaptic dysfunction in PD. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s12264-024-01188-0Test; https://pubmed.ncbi.nlm.nih.gov/38483697Test |
| DOI: | 10.1007/s12264-024-01188-0 |
| الإتاحة: | https://doi.org/10.1007/s12264-024-01188-0Test https://pubmed.ncbi.nlm.nih.gov/38483697Test |
| حقوق: | © 2024. Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences. |
| رقم الانضمام: | edsbas.E0ED0E1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s12264-024-01188-0 |
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