دورية أكاديمية
Atherosclerotic Coronary Plaque Features in Patients With Chronic Obstructive Pulmonary Disease and Acute Coronary Syndrome.
| العنوان: | Atherosclerotic Coronary Plaque Features in Patients With Chronic Obstructive Pulmonary Disease and Acute Coronary Syndrome. |
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| المؤلفون: | Russo, Michele, Camilli, Massimiliano, La Vecchia, Giulia, Rinaldi, Riccardo, Bonanni, Alice, Natale, Matteo Pio, Salzillo, Carmine, Torre, Ilaria, Trani, Carlo, Crea, Filippo, Montone, Rocco A |
| المصدر: | Am J Cardiol ; ISSN:1879-1913 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | chronic obstructive pulmonary disease, highlights, optical coherence tomography, plaque inflammation, vulnerable plaque |
| الوصف: | Previous studies reported a robust relation between chronic obstructive pulmonary disease (COPD) and coronary artery disease (CAD). Systemic inflammation has been proposed as possible pathogenetic mechanism linking these 2 entities, although data on atherosclerotic coronary features in COPD patients are lacking. We studied atherosclerotic coronary plaque features in COPD patients presenting with acute coronary syndrome (ACS) using optical coherence tomography (OCT). ACS patients who underwent intracoronary OCT imaging of the culprit vessel were enrolled. Coronary plaque characteristics and OCT-defined macrophage infiltration (MØI) were assessed by OCT. ACS patients were divided into 2 groups according to the presence of an established diagnosis of COPD, and plaque features at the culprit site and along the culprit vessel were compared between the groups. Of 146 ACS patients (mean age:66.1 ± 12.7 years, 109 men), 47 (32.2%) had COPD. Patients with COPD had significantly higher prevalence of MØI (78.7% vs 54.5%, p = 0.005) and thin cap fibroatheroma (TCFA) (48.9% vs 22.2%, p = 0.001) at the culprit site. In the multivariate logistic regression, COPD was independently associated with MØI (odds ratio [OR] 21.209, 95% confidence interval [CI] 1.679 to 267.910, p = 0.018) and TCFA at the culprit site (OR 5.345, 95% CI 1.386 to 20.616, p = 0.015). Similarly, COPD was independently associated with both MØI (OR 3.570, 95% CI 1.472 to 8.658, p = 0.005) and TCFA (OR 4.088, 95% CI 1.584 to 10.554, p = 0.004) along the culprit vessel. In conclusion, in ACS patients who underwent OCT imaging of the culprit vessel, COPD was an independent predictor of plaque inflammation and vulnerability. These results may suggest that a higher inflammatory milieu in COPD patients might enhance local coronary inflammation, promoting CAD development and plaque vulnerability. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.amjcard.2024.06.005Test; https://pubmed.ncbi.nlm.nih.gov/38871157Test |
| DOI: | 10.1016/j.amjcard.2024.06.005 |
| الإتاحة: | https://doi.org/10.1016/j.amjcard.2024.06.005Test https://pubmed.ncbi.nlm.nih.gov/38871157Test |
| حقوق: | Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.F86F1649 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.amjcard.2024.06.005 |
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