دورية أكاديمية
An immune-based biomarker signature is associated with mortality in COVID-19 patients.
| العنوان: | An immune-based biomarker signature is associated with mortality in COVID-19 patients. |
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| المؤلفون: | Abers, Michael S, Delmonte, Ottavia M, Ricotta, Emily E, Fintzi, Jonathan, Fink, Danielle L, de Jesus, Adriana A Almeida, Zarember, Kol A, Alehashemi, Sara, Oikonomou, Vasileios, Desai, Jigar V, Canna, Scott W, Shakoory, Bita, Dobbs, Kerry, Imberti, Luisa, Sottini, Alessandra, Quiros-Roldan, Eugenia, Castelli, Francesco, Rossi, Camillo, Brugnoni, Duilio, Biondi, Andrea, Bettini, Laura Rachele, D'Angio', Mariella, Bonfanti, Paolo, Castagnoli, Riccardo, Montagna, Daniela, Licari, Amelia, Marseglia, Gian Luigi, Gliniewicz, Emily F, Shaw, Elana, Kahle, Dana E, Rastegar, Andre T, Stack, Michael, Myint-Hpu, Katherine, Levinson, Susan L, DiNubile, Mark J, Chertow, Daniel W, Burbelo, Peter D, Cohen, Jeffrey I, Calvo, Katherine R, Tsang, John S, Su, Helen C, Gallin, John I, Kuhns, Douglas B, Goldbach-Mansky, Raphaela, Lionakis, Michail S, Notarangelo, Luigi D |
| المصدر: | JCI Insight ; ISSN:2379-3708 ; Volume:6 ; Issue:1 |
| بيانات النشر: | American Society for Clinical Investigation |
| سنة النشر: | 2021 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | COVID-19, Chemokines, Cytokines, Immunology |
| الوصف: | Immune and inflammatory responses to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contribute to disease severity of coronavirus disease 2019 (COVID-19). However, the utility of specific immune-based biomarkers to predict clinical outcome remains elusive. Here, we analyzed levels of 66 soluble biomarkers in 175 Italian patients with COVID-19 ranging from mild/moderate to critical severity and assessed type I IFN-, type II IFN-, and NF-κB-dependent whole-blood transcriptional signatures. A broad inflammatory signature was observed, implicating activation of various immune and nonhematopoietic cell subsets. Discordance between IFN-α2a protein and IFNA2 transcript levels in blood suggests that type I IFNs during COVID-19 may be primarily produced by tissue-resident cells. Multivariable analysis of patients' first samples revealed 12 biomarkers (CCL2, IL-15, soluble ST2 [sST2], NGAL, sTNFRSF1A, ferritin, IL-6, S100A9, MMP-9, IL-2, sVEGFR1, IL-10) that when increased were independently associated with mortality. Multivariate analyses of longitudinal biomarker trajectories identified 8 of the aforementioned biomarkers (IL-15, IL-2, NGAL, CCL2, MMP-9, sTNFRSF1A, sST2, IL-10) and 2 additional biomarkers (lactoferrin, CXCL9) that were substantially associated with mortality when increased, while IL-1α was associated with mortality when decreased. Among these, sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1172/jci.insight.144455Test; https://pubmed.ncbi.nlm.nih.gov/33232303Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821609Test/ |
| DOI: | 10.1172/jci.insight.144455 |
| الإتاحة: | https://doi.org/10.1172/jci.insight.144455Test https://pubmed.ncbi.nlm.nih.gov/33232303Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821609Test/ |
| رقم الانضمام: | edsbas.C5588CC9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1172/jci.insight.144455 |
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