دورية أكاديمية
Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer.
| العنوان: | Exploratory biomarker analysis in the phase III L-MOCA study of olaparib maintenance therapy in patients with platinum-sensitive relapsed ovarian cancer. |
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| المؤلفون: | Li, Huayi, Peng, Zikun, Zhu, Jianqing, Zhao, Weidong, Huang, Yi, An, Ruifang, Zheng, Hong, Qu, Pengpeng, Wang, Li, Zhou, Qi, Wang, Danbo, Lou, Ge, Wang, Jing, Wang, Ke, Kong, Beihua, Xie, Xing, Yin, Rutie, Low, John, Rozita, Abdul Malik, Sen, Lim Chun, Meng, Yong Chee, Kiong, Kho Swee, Liu, Jihong, Liang, Zhiqing, Lv, Weiguo, Zhu, Yaping, Hu, Weiguo, Sun, Wei, Su, Jingya, Wang, Qiqi, Zang, Rongyu, Ma, Ding, Gao, Qinglei |
| المصدر: | BMC Med ; ISSN:1741-7015 ; Volume:22 ; Issue:1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | BRCA1/2, Biomarker, Homologous recombination deficiency, L-MOCA trial, Olaparib, PARP inhibitors, PD-L1 expression, Platinum-sensitive relapsed ovarian cancer |
| الوصف: | The prospective phase III multi-centre L-MOCA trial (NCT03534453) has demonstrated the encouraging efficacy and manageable safety profile of olaparib maintenance therapy in the Asian (mainly Chinese) patients with platinum-sensitive relapsed ovarian cancer (PSROC). In this study, we report the preplanned exploratory biomarker analysis of the L-MOCA trial, which investigated the effects of homologous recombination deficiency (HRD) and programmed cell death ligand 1 (PD-L1) expression on olaparib efficacy. |
| نوع الوثيقة: | article in journal/newspaper report |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1186/s12916-024-03409-9Test; https://pubmed.ncbi.nlm.nih.gov/38755585Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100112Test/ |
| DOI: | 10.1186/s12916-024-03409-9 |
| الإتاحة: | https://doi.org/10.1186/s12916-024-03409-9Test https://pubmed.ncbi.nlm.nih.gov/38755585Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11100112Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.A032D716 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12916-024-03409-9 |
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