دورية أكاديمية
Prevention, diagnosis and clinical management of hereditary breast cancer beyond BRCA1/2 genes.
| العنوان: | Prevention, diagnosis and clinical management of hereditary breast cancer beyond BRCA1/2 genes. |
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| المؤلفون: | Calabrese, A, von Arx, C, Tafuti, A A, Pensabene, M, De Laurentiis, M |
| المصدر: | Cancer Treat Rev ; ISSN:1532-1967 ; Volume:129 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | BRCA genes, Hereditary breast cancer, Multi-gene panel testing, NGS, VUS |
| الوصف: | The detection of germline pathogenic variants (gPVs) in BRCA1/2 and other breast cancer (BC) genes is rising exponentially thanks to the advent of multi-gene panel testing. This promising technology, coupled with the availability of specific therapies for BC BRCA-related, has increased the number of patients eligible for genetic testing. Implementing multi-gene panel testing for hereditary BC screening holds promise to maximise benefits for patients at hereditary risk of BC. These benefits range from prevention programs to antineoplastic-targeted therapies. However, the clinical management of these patients is complex and requires guidelines based on recent evidence. Furthermore, applying multi-gene panel testing into clinical practice increases the detection of variants of uncertain significance (VUSs). This augments the complexity of patients' clinical management, becoming an unmet need for medical oncologists. This review aims to collect updated evidence on the most common BC-related genes besides BRCA1/2, from their biological role in BC development to their potential impact in tailoring prevention and treatment strategies. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.ctrv.2024.102785Test; https://pubmed.ncbi.nlm.nih.gov/38870570Test |
| DOI: | 10.1016/j.ctrv.2024.102785 |
| الإتاحة: | https://doi.org/10.1016/j.ctrv.2024.102785Test https://pubmed.ncbi.nlm.nih.gov/38870570Test |
| حقوق: | Copyright © 2024. Published by Elsevier Ltd. |
| رقم الانضمام: | edsbas.EB882ED1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ctrv.2024.102785 |
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