دورية أكاديمية
Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI.
| العنوان: | Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI. |
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| المؤلفون: | Terenzi, Damiano, Simon, Nicolas, Gachomba, Michael Joe Munyua, de Peretti, Jeanne-Laure, Nazarian, Bruno, Sein, Julien, Anton, Jean-Luc, Grandjean, Didier, Baunez, Christelle, Chaminade, Thierry |
| المصدر: | Mol Psychiatry ; ISSN:1476-5578 |
| بيانات النشر: | Nature Publishing Group |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Addictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no neurobiological study investigating this mediation in humans. This study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI "Social" Stop-Signal Task (SSST) in the presence or absence of an observer while being exposed to cocaine-related (vs. neutral) cues eliciting craving in drug users. The results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. During inhibition (Stop Correct vs Stop Incorrect), activity in the right STN, right inferior frontal gyrus (IFG), and bilateral orbitofrontal cortex (OFC) varied according to the type of cue. Notably, the presence of an observer reversed this effect in most areas for CUD participants. These findings highlight the impact of social context and drug cues on inhibitory control in CUD and the mediation of these effects by the right STN and bilateral OFC, emphasizing the importance of considering the social context in addiction research. They also comfort the STN as a potential addiction treatment target. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1038/s41380-024-02637-yTest; https://pubmed.ncbi.nlm.nih.gov/38926543Test |
| DOI: | 10.1038/s41380-024-02637-y |
| الإتاحة: | https://doi.org/10.1038/s41380-024-02637-yTest https://pubmed.ncbi.nlm.nih.gov/38926543Test |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.7F7B2FA1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41380-024-02637-y |
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