المؤلفون: Ende, Holly B, Habib, Ashraf S, Lim, Grace, Landau, Ruth, Beilin, Yaakov, Wong, Cynthia A

المصدر: Br J Anaesth ; ISSN:1471-6771

مصطلحات موضوعية: anaesthetic neurotoxicity, behavioural deficit, maternal surgery, neurodevelopment, paediatric anaesthesia, prenatal exposure

العلاقة: https://doi.org/10.1016/j.bja.2024.05.023Test; https://pubmed.ncbi.nlm.nih.gov/38942643Test

الإتاحة: https://doi.org/10.1016/j.bja.2024.05.023Test
https://pubmed.ncbi.nlm.nih.gov/38942643Test

المؤلفون: Sundbakk, Lene Maria, Wood, Mollie, Gran, Jon Michael, Nordeng, Hedvig

المصدر: Am J Epidemiol ; ISSN:1476-6256

مصطلحات موضوعية: Father and Child Cohort Study (MoBa), Norwegian Mother, child neurodevelopment, mental health, pharmacoepidemiology, pregnancy, prenatal exposure, school performance, target trial emulation

الوصف: Evidence is limited regarding the effect of prenatal benzodiazepine and z-hypnotic exposure and long-term neurodevelopment in childhood. The objective of this study was to investigate the effects of initiating benzodiazepine or z-hypnotic treatment in early, mid and late pregnancy on fifth-grade numeracy and literacy scholastic skills in children, by emulating three target trials. The trials are identical except for the timing of enrollment and the number of eligible individuals. Eligibility to the trials required a history of anxiety and/or depression prior to pregnancy. We used data from the Norwegian Mother, Father and Child Cohort Study, linked to the Medical Birth Registry of Norway, to emulate the trials. We adjusted for baseline covariates that were available at time 0 for each trial by inverse probability of treatment weighting using the propensity score. The findings of this study did not show any effect of mothers' initiation of treatment with benzodiazepines or z-hypnotics in early, mid or late pregnancy on the children's 5th grade test scores in numeracy and literacy. The study results provide reassurance for patients in need of benzodiazepines and z-hypnotics during pregnancy; however, these findings need to be interpreted with caution due to low study power in some of the analyses.

العلاقة: https://doi.org/10.1093/aje/kwae159Test; https://pubmed.ncbi.nlm.nih.gov/38944758Test

الإتاحة: https://doi.org/10.1093/aje/kwae159Test
https://pubmed.ncbi.nlm.nih.gov/38944758Test

المؤلفون: Thurston, Sally W, Ruppert, David, Korrick, Susan A

المصدر: Am J Epidemiol ; ISSN:1476-6256

مصطلحات موضوعية: epidemiology, fish consumption, mercury exposure assessment, methylmercury, neurodevelopment, prenatal exposure

الوصف: Understanding health risks from methylmercury (MeHg) exposure is complicated by its link to fish consumption which may confound or modify toxicities. One solution is to include fish intake and a biomarker of MeHg exposure in the same model, but resulting estimates do not reflect the independent impact of accumulated MeHg or fish exposures. In fish-eating populations, this can be addressed by separating MeHg exposure into fish intake and average Hg content of the consumed fish. We assessed the joint association of prenatal MeHg exposure (maternal hair Hg) and fish intake (among fish-eating mothers) with neurodevelopment in 361 eight-year-olds from the New Bedford Cohort (born 1993-1998). Neurodevelopmental assessments used standardized tests of IQ, language, memory, and attention. Covariate-adjusted regression assessed the association of maternal fish consumption, stratified by tertiles of estimated average fish Hg, with neurodevelopment. Associations between maternal fish intake and child outcomes were generally beneficial for those in the lowest average fish Hg tertile, but detrimental in the highest average fish Hg tertile where, for example, each serving of fish was associated with 1.3 fewer correct responses (95% CI: -2.2, -0.4) on the Boston Naming test. Standard analyses showed no outcome associations with hair Hg or fish intake.

العلاقة: https://doi.org/10.1093/aje/kwae149Test; https://pubmed.ncbi.nlm.nih.gov/38940366Test

الإتاحة: https://doi.org/10.1093/aje/kwae149Test
https://pubmed.ncbi.nlm.nih.gov/38940366Test

المؤلفون: Qiu, Feng, Zhang, Hongling, Wang, Xin, Jia, Zhenxian, He, Yujie, Wu, Yi, Li, Zhangpeng, Zheng, Tongzhang, Xia, Wei, Xu, Shunqing, Li, Yuanyuan

المصدر: Environ Sci Pollut Res Int ; ISSN:1614-7499 ; Volume:31 ; Issue:26

مصطلحات موضوعية: Arsenic metabolism, Cord blood, Mitochondrial DNA copy number, Prenatal exposure, Repeated measurement

الوصف: While mitochondria are susceptible to environmental detriments, little is known about potential associations between arsenic metabolites and mitochondria DNA copy number (mtDNAcn). We attempted to examine whether maternal urinary arsenic metabolite levels in different trimesters were related to neonatal cord blood mtDNAcn. We included 819 mother-newborn pairs embedded in an in-progress birth cohort survey performed from April 2014 to October 2016 in Wuhan, China. We determined maternal urinary arsenic species concentrations in different trimesters. We determined cord blood mtDNAcn using quantitative real-time polymerase chain reaction. In covariate-adjusted models, each one-unit increment of dimethylated arsenic (DMA) and total arsenic (TAs) in the third trimester was related to 8.43% (95% CI 1.13%, 16.26%) and 12.15% (95% CI 4.35%, 20.53%) increases in mtDNAcn, respectively. The dose-response trend with statistical significance was observed across tertiles of DMA and TAs in the third trimester with mtDNAcn (DMA percent changes (%Δ) = 25.60 (95% CI 6.73, 47.82), for the highest vs the lowest tertile (P = 0.02); TAs %Δ = 40.31 (95% CI 19.25, 65.10), for the highest vs the lowest tertile (P = 0.0002)). These findings may prove the relationships between prenatal arsenic species levels and neonatal mitochondrial dysfunction.

العلاقة: https://doi.org/10.1007/s11356-024-32933-7Test; https://pubmed.ncbi.nlm.nih.gov/38789711Test

الإتاحة: https://doi.org/10.1007/s11356-024-32933-7Test
https://pubmed.ncbi.nlm.nih.gov/38789711Test

المؤلفون: Malin Igra, Annachiara, Trask, Mercedes, Rahman, Syed Moshfiqur, Dreij, Kristian, Lindh, Christian, Krais, Annette M, Persson, Lars-Åke, Rahman, Anisur, Kippler, Maria

المصدر: Environ Int ; ISSN:1873-6750 ; Volume:189

مصطلحات موضوعية: Fluorene, Menarche, Phenanthrene, Polycyclic aromatic hydrocarbons, Prenatal exposure, Pyrene

الوصف: In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenous.

العلاقة: https://doi.org/10.1016/j.envint.2024.108798Test; https://pubmed.ncbi.nlm.nih.gov/38875814Test

الإتاحة: https://doi.org/10.1016/j.envint.2024.108798Test
https://pubmed.ncbi.nlm.nih.gov/38875814Test

المؤلفون: Wu, Tiancheng, Huang, Jing, Li, Yating, Guo, Yu, Wang, Hui, Zhang, Yuanzhen

المصدر: Food Chem Toxicol ; ISSN:1873-6351 ; Volume:189

مصطلحات موضوعية: Acetaminophen, Oocyte, Ovarian developmental toxicity, Pre-granulosa cell, Prenatal exposure

الوصف: Acetaminophen is an emerging endocrine disrupting chemical and has been detected in various natural matrices. Numerous studies have documented developmental toxicity associated with prenatal acetaminophen exposure (PAcE). In this study, we established a PAcE Kunming mouse model at different time (middle pregnancy and third trimester), doses (low, middle, high) and courses (single or multi-) to systematically investigate their effects on fetal ovarian development. The findings indicated PAcE affected ovarian development, reduced fetal ovarian oocyte number and inhibited cell proliferation. A reduction in mRNA expression was observed for genes associated with oocyte markers (NOBOX and Figlα), follicular development markers (BMP15 and GDF9), and pre-granulosa cell steroid synthase (SF1 and StAR). Notably, exposure in middle pregnancy, high dose, multi-course resulted in the most pronounced inhibition of oocyte development; exposure in third trimester, high dose and multi-course led to the most pronounced inhibition of follicular development; and in third trimester, low dose and single course, the inhibition of pre-granulosa cell function was most pronounced. Mechanistic investigations revealed that PAcE had the most pronounced suppression of the ovarian Notch signaling pathway. Overall, PAcE caused fetal ovarian multicellular toxicity and inhibited follicular development with time, dose and course differences.

العلاقة: https://doi.org/10.1016/j.fct.2024.114679Test; https://pubmed.ncbi.nlm.nih.gov/38657942Test

الإتاحة: https://doi.org/10.1016/j.fct.2024.114679Test
https://pubmed.ncbi.nlm.nih.gov/38657942Test

المؤلفون: Choi, Jeong Weon, Oh, Jiwon, Bennett, Deborah H, Calafat, Antonia M, Schmidt, Rebecca J, Shin, Hyeong-Moo

المصدر: Environ Res ; ISSN:1096-0953 ; Volume:251 ; Issue:Pt 1

مصطلحات موضوعية: Behavioral problems, Per- and polyfluoroalkyl substances, Prenatal exposure

الوصف: Prenatal exposure to per- and polyfluoroalkyl substances (PFAS) may adversely affect child behaviors; however, findings of epidemiologic studies are inconsistent. We examined prenatal PFAS exposure in association with child behavioral problems.

العلاقة: https://doi.org/10.1016/j.envres.2024.118511Test; https://pubmed.ncbi.nlm.nih.gov/38387490Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144101Test/

الإتاحة: https://doi.org/10.1016/j.envres.2024.118511Test
https://pubmed.ncbi.nlm.nih.gov/38387490Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11144101Test/

المؤلفون: Rosa, Maria José, Politis, Maria D, Tamayo-Ortiz, Marcela, Colicino, Elena, Pantic, Ivan, Estrada-Gutierrez, Guadalupe, Tolentino, Mari Cruz, Espejel-Nuñez, Aurora, Solano-Gonzalez, Maritsa, Kloog, Itai, Rivera, Nadya Rivera, Baccarelli, Andrea A, Tellez-Rojo, Martha M, Wright, Robert O, Just, Allan C, Sanders, Alison P

المصدر: Environ Res ; ISSN:1096-0953 ; Volume:204 ; Issue:Pt B

مصطلحات موضوعية: Bayesian distributed lag interaction models, Distributed lag models, Kidney function, Particulate matter, Prenatal exposure

الوصف: Air pollution exposure, especially particulate matter ≤2.5 μm in diameter (PM2.5), is associated with poorer kidney function in adults and children. Perinatal exposure may occur during susceptible periods of nephron development. We used distributed lag nonlinear models (DLNMs) to examine time-varying associations between early life daily PM2.5 exposure (periconceptional through age 8 years) and kidney parameters in preadolescent children aged 8-10 years. Participants included 427 mother-child dyads enrolled in the PROGRESS birth cohort study based in Mexico City. Daily PM2.5 exposure was estimated at each participant's residence using a validated satellite-based spatio-temporal model. Kidney function parameters included estimated glomerular filtration rate (eGFR), serum cystatin C, and blood urea nitrogen (BUN). Models were adjusted for child's age, sex and body mass index (BMI) z-score, as well as maternal education, indoor smoking report and seasonality (prenatal models were additionally adjusted for average first year of life PM2.5 exposure). We also tested for sex-specific effects. Average perinatal PM2.5 was 22.7 μg/m3 and ranged 16.4-29.3 μg/m3. Early pregnancy PM2.5 exposures were associated with higher eGFR in preadolescence. Specifically, we found that PM2.5 exposure between weeks 1-18 of gestation was associated with increased preadolescent eGFR, whereas exposure in the first 14 months of life after birth were associated with decreased eGFR. Specifically, a 5 μg/m3 increase in PM2.5 during the detected prenatal window was associated with a cumulative increase in eGFR of 4.44 mL/min/1.732 (95%CI: 1.37, 7.52), and during the postnatal window we report a cumulative eGFR decrease of -10.36 mL/min/1.732 (95%CI: -17.68, -3.04). We identified perinatal windows of susceptibility to PM2.5 exposure with preadolescent kidney function parameters. Follow-up investigating PM2.5 exposure with peripubertal kidney function trajectories and risk of kidney disease in adulthood will be critical.

العلاقة: https://doi.org/10.1016/j.envres.2021.112062Test; https://pubmed.ncbi.nlm.nih.gov/34537199Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678189Test/

الإتاحة: https://doi.org/10.1016/j.envres.2021.112062Test
https://pubmed.ncbi.nlm.nih.gov/34537199Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8678189Test/

المؤلفون: Yesildemir, Ozge, Celik, Mensure Nur

المصدر: Curr Nutr Rep ; ISSN:2161-3311

مصطلحات موضوعية: Children, Environmental pollutants, Postnatal exposure, Prenatal exposure, Reproduction, Reproductive health

الوصف: Environmental pollutants in air, water, soil, and food are a significant concern due to their potential adverse effects on fetuses, newborns, babies, and children. These chemicals, which pass to fetuses and babies through trans-placental transfer, breast milk, infant formula, dermal transfer, and non-nutritive ingestion, can cause health problems during childhood. This review aims to discuss how exposure to various environmental pollutants in early life stages can disrupt reproductive health in children.

العلاقة: https://doi.org/10.1007/s13668-024-00557-5Test; https://pubmed.ncbi.nlm.nih.gov/38935249Test

الإتاحة: https://doi.org/10.1007/s13668-024-00557-5Test
https://pubmed.ncbi.nlm.nih.gov/38935249Test

المؤلفون: Warmington, Anastasia V, Bowdish, Dawn M E, Sherifali, Diana, Sloboda, Deborah M

المصدر: AJPM Focus ; ISSN:2773-0654 ; Volume:3 ; Issue:4

مصطلحات موضوعية: Maternal obesity, child health, prenatal exposure delayed effects, respiratory infection

الوصف: Pregnancy complications, including high maternal BMI, are associated with altered early development and child health outcomes. A growing body of work links the prenatal environment, specifically maternal BMI, with respiratory infections in offspring. In this rapid review, the authors review the literature supporting the hypothesis that high maternal BMI during pregnancy is associated with childhood respiratory infection incidence.

العلاقة: https://doi.org/10.1016/j.focus.2024.100234Test; https://pubmed.ncbi.nlm.nih.gov/38933528Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200298Test/

الإتاحة: https://doi.org/10.1016/j.focus.2024.100234Test
https://pubmed.ncbi.nlm.nih.gov/38933528Test
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11200298Test/