دورية أكاديمية
Investigating the multifaceted cooperation of autophagy, PI3K/AKT signaling pathways, and INPP4B gene in de novo acute myeloid leukemia patients.
| العنوان: | Investigating the multifaceted cooperation of autophagy, PI3K/AKT signaling pathways, and INPP4B gene in de novo acute myeloid leukemia patients. |
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| المؤلفون: | Gorji, Mahnaz, Farsani, Mehdi Allahbakhshian, Kargar, Maryam, Garavand, Javad, Mohammadi, Mohammad Hossein |
| المصدر: | Curr Res Transl Med ; ISSN:2452-3186 ; Volume:72 ; Issue:2 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | AML, Autophagy, Gene expression, INPP4B, PI3K-AKT pathway |
| الوصف: | Acute myeloid leukemia (AML) has been the most prevalent form of acute leukemia among adults, and it has been associated with poor survival rates over the last four decades. Understanding the processes involved in leukemogenesis, particularly autophagy and signaling pathways, can provide critical insights into their roles in disease development, risk assessment, and potential therapeutic interventions. This study investigated gene expression changes, focusing on MAP1LC3B and BECN1, related to autophagy, as well as PI3KCA and AKT1 in the PI3K-AKT pathway, and INPP4B, which regulates this signaling cascade. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.retram.2023.103429Test; https://pubmed.ncbi.nlm.nih.gov/38246071Test |
| DOI: | 10.1016/j.retram.2023.103429 |
| الإتاحة: | https://doi.org/10.1016/j.retram.2023.103429Test https://pubmed.ncbi.nlm.nih.gov/38246071Test |
| حقوق: | Copyright © 2023. Published by Elsevier Masson SAS. |
| رقم الانضمام: | edsbas.5914DAC6 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.retram.2023.103429 |
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