دورية أكاديمية
| العنوان: | [Untitled] |
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| المؤلفون: | Yang, Caixin, Lan, Ruiting, Zhao, Lijun, Pu, Ji, Hu, Dalong, Yang, Jing, Zhou, Huimin, Han, Lichao, Ye, Lin, Jin, Dong, Xu, Jianguo, Liu, Liyun |
| المصدر: | mSystems ; ISSN:2379-5077 |
| بيانات النشر: | Atypon |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | GLP-1, Prevotella copri, gut microbiota, hyperglycemia, metabolism |
| الوصف: | Prevotella copri is the dominant species of the Prevotella genus in the gut, which is genomically heterogeneous and difficult to isolate; hence, scarce research was carried out for this species. This study aimed to investigate the effect of P. copri on hyperglycemia. Thirty-nine strains were isolated from healthy individuals, and three strains (HF2123, HF1478, and HF2130) that had the highest glucose consumption were selected to evaluate the effects of P. copri supplementation on hyperglycemia. Microbiomics and non-target metabolomics were used to uncover the underlying mechanisms. Oral administration of P. copri in diabetic db/db mice increased the expression and secretion of glucagon-like peptide-1 (GLP-1), significantly improved hyperglycemia, insulin resistance, and lipid accumulation, and alleviated the pathological morphology in the pancreas, liver, and colon. P. copri changed the composition of the gut microbiota of diabetic db/db mice, which was characterized by increasing the ratio of Bacteroidetes to Firmicutes and increasing the relative abundance of genera Bacteroides, Akkermansia, and Faecalibacterium. After intervention with P. copri, fecal metabolic profiling showed that fumaric acid and homocysteine contents decreased, and glutamine contents increased. Furthermore, amino acid metabolism and cAMP/PKA signaling pathways were enriched. Our findings indicate that P. copri improved glucose metabolism abnormalities in diabetic db/db mice. Especially, one of the P. copri strains, HF2130, has shown superior performance in improving hyperglycemia, which may have the potential as a probiotic against hyperglycemia. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1128/msystems.00532-24Test; https://pubmed.ncbi.nlm.nih.gov/38934548Test |
| DOI: | 10.1128/msystems.00532-24 |
| الإتاحة: | https://doi.org/10.1128/msystems.00532-24Test https://pubmed.ncbi.nlm.nih.gov/38934548Test |
| رقم الانضمام: | edsbas.7FC01712 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1128/msystems.00532-24 |
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