دورية أكاديمية
COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma.
| العنوان: | COL10A1 expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma. |
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| المؤلفون: | Esposito, Mauro, Yerly, Laura, Shukla, Prachi, Hermes, Victoria, Sella, Federica, Balazs, Zsolt, Lattmann, Evelyn, Tastanova, Aizhan, Turko, Patrick, Lang, Ramon, Kolm, Isabel, Staeger, Ramon, Kuonen, François, Krauthammer, Michael, Hafner, Juerg, Levesque, Mitchell P, Restivo, Gaetana |
| المصدر: | Br J Dermatol ; ISSN:1365-2133 |
| بيانات النشر: | Silverchair Information Systems |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Basal cell carcinoma (BCC) is the most frequently diagnosed skin cancer and the most common malignancy in humans. Different morphological subtypes of BCC are associated with low- or high-risk of recurrence and aggressiveness, but the underlying biology of how the individual subtypes arise remains largely unknown. Because the majority of BCCs appear to arise from mutations in the same pathway, we hypothesized that BCC development, growth and invasive potential is also influenced by the tumor microenvironment and in particular by cancer-associated fibroblasts (CAFs) and their secreted factors. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1093/bjd/ljae258Test; https://pubmed.ncbi.nlm.nih.gov/38916477Test |
| DOI: | 10.1093/bjd/ljae258 |
| الإتاحة: | https://doi.org/10.1093/bjd/ljae258Test https://pubmed.ncbi.nlm.nih.gov/38916477Test |
| حقوق: | © The Author(s) 2024. Published by Oxford University Press on behalf of British Association of Dermatologists. |
| رقم الانضمام: | edsbas.1559A89C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/bjd/ljae258 |
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