دورية أكاديمية
Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection.
| العنوان: | Pharmacokinetics, Pharmacodynamics, and Safety of Lisinopril in Pediatric Kidney Transplant Patients: Implications for Starting Dose Selection. |
|---|---|
| المؤلفون: | Trachtman, H, Frymoyer, A, Lewandowski, A, Greenbaum, L A, Feig, D I, Gipson, D S, Warady, B A, Goebel, J W, Schwartz, G J, Lewis, K, Anand, R, Patel, U D |
| المصدر: | Clin Pharmacol Ther ; ISSN:1532-6535 ; Volume:98 ; Issue:1 |
| بيانات النشر: | Wiley |
| سنة النشر: | 2015 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Hypertension in pediatric kidney transplant recipients contributes to long-term graft loss, yet treatment options--including angiotensin-converting enzyme inhibitors--are poorly characterized in this vulnerable population. We conducted a multicenter, open-label pharmacokinetic (PK) study of daily oral lisinopril in 22 children (ages 7-17 years) with stable kidney transplant function. Standard noncompartmental PK analyses were performed at steady state. Effects on blood pressure were examined in lisinopril-naïve patients (n = 13). Oral clearance declined in proportion to underlying kidney function; however, in patients with low estimated glomerular filtration rate (30-59 ml/min per 1.73m(2)), exposure (standardized to 0.1 mg/kg/day dose) was within the range reported previously in children without a kidney transplant. In lisinopril-naïve patients, 85% and 77% had a ≥ 6 mmHg reduction in systolic and diastolic blood pressure, respectively. Lisinopril was well tolerated. Our study provides initial insight on lisinopril use in children with a kidney transplant, including starting dose considerations. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1002/cpt.127Test; https://pubmed.ncbi.nlm.nih.gov/25807932Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536255Test/ |
| DOI: | 10.1002/cpt.127 |
| الإتاحة: | https://doi.org/10.1002/cpt.127Test https://pubmed.ncbi.nlm.nih.gov/25807932Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4536255Test/ |
| حقوق: | © 2015 American Society for Clinical Pharmacology and Therapeutics. |
| رقم الانضمام: | edsbas.EA7AF66A |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/cpt.127 |
|---|