دورية أكاديمية
Memory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies.
| العنوان: | Memory loss and aberrant neurogenesis in mice exposed to patient anti-N-methyl-d-aspartate receptor antibodies. |
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| المؤلفون: | Taraschenko, Olga, Fox, Howard S, Heliso, Priscilla, Al-Saleem, Fetweh, Dessain, Scott, Kim, Woo-Yang, Samuelson, Mystera M, Dingledine, Raymond |
| المصدر: | Exp Neurol ; ISSN:1090-2430 ; Volume:378 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Aberrant neurogenesis, Anti-NMDA receptor encephalitis, Antibody-induced seizures, Autoimmune encephalitis, Cognitive failure in encephalitis, Memory loss |
| الوصف: | Anti-N-methyl-d-aspartate receptor (anti-NMDAR) encephalitis results in chronic epilepsy and permanent cognitive impairment. One of the possible causes of cognitive impairment in anti-NMDAR could be aberrant neurogenesis, an established contributor to memory loss in idiopathic drug-resistant epilepsy. We developed a mouse model of anti-NMDAR encephalitis and showed that mice exposed to patient anti-NMDAR antibodies for 2 weeks developed seizures and memory loss. In the present study, we assessed the delayed effects of patient-derived antibodies on cognitive phenotype and examined the corresponding changes in hippocampal neurogenesis. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.expneurol.2024.114838Test; https://pubmed.ncbi.nlm.nih.gov/38801989Test |
| DOI: | 10.1016/j.expneurol.2024.114838 |
| الإتاحة: | https://doi.org/10.1016/j.expneurol.2024.114838Test https://pubmed.ncbi.nlm.nih.gov/38801989Test |
| حقوق: | Copyright © 2024 Elsevier Inc. All rights reserved. |
| رقم الانضمام: | edsbas.164AC8AB |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.expneurol.2024.114838 |
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