دورية أكاديمية
Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway.
| العنوان: | Trophoblast-derived miR-410-5p induces M2 macrophage polarization and mediates immunotolerance at the fetal-maternal interface by targeting the STAT1 signaling pathway. |
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| المؤلفون: | Yang, Jing, Li, Longfei, Wang, Linlin, Chen, Ruizhi, Yang, Xiaobing, Wu, Juanhua, Feng, Gang, Ding, Jinli, Diao, Lianghui, Chen, Jiao |
| المصدر: | J Transl Med ; ISSN:1479-5876 ; Volume:22 ; Issue:1 |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Fetal-maternal cross-talk, Immunotolerance, Macrophage polarization, Spontaneous miscarriage, miR-410-5p |
| الوصف: | Macrophages phenotypic deviation and immune imbalance play vital roles in pregnancy-associated diseases such as spontaneous miscarriage. Trophoblasts regulate phenotypic changes in macrophages, however, their underlying mechanism during pregnancy remains unclear. Therefore, this study aimed to elucidate the potential function of trophoblast-derived miRNAs (miR-410-5p) in macrophage polarization during pregnancy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1186/s12967-023-04831-yTest; https://pubmed.ncbi.nlm.nih.gov/38178171Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768263Test/ |
| DOI: | 10.1186/s12967-023-04831-y |
| الإتاحة: | https://doi.org/10.1186/s12967-023-04831-yTest https://pubmed.ncbi.nlm.nih.gov/38178171Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10768263Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.793DCFBC |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12967-023-04831-y |
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