دورية أكاديمية
Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study.
| العنوان: | Prenatal arsenic metabolite exposure is associated with increased newborn mitochondrial DNA copy number: evidence from a birth cohort study. |
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| المؤلفون: | Qiu, Feng, Zhang, Hongling, Wang, Xin, Jia, Zhenxian, He, Yujie, Wu, Yi, Li, Zhangpeng, Zheng, Tongzhang, Xia, Wei, Xu, Shunqing, Li, Yuanyuan |
| المصدر: | Environ Sci Pollut Res Int ; ISSN:1614-7499 ; Volume:31 ; Issue:26 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Arsenic metabolism, Cord blood, Mitochondrial DNA copy number, Prenatal exposure, Repeated measurement |
| الوصف: | While mitochondria are susceptible to environmental detriments, little is known about potential associations between arsenic metabolites and mitochondria DNA copy number (mtDNAcn). We attempted to examine whether maternal urinary arsenic metabolite levels in different trimesters were related to neonatal cord blood mtDNAcn. We included 819 mother-newborn pairs embedded in an in-progress birth cohort survey performed from April 2014 to October 2016 in Wuhan, China. We determined maternal urinary arsenic species concentrations in different trimesters. We determined cord blood mtDNAcn using quantitative real-time polymerase chain reaction. In covariate-adjusted models, each one-unit increment of dimethylated arsenic (DMA) and total arsenic (TAs) in the third trimester was related to 8.43% (95% CI 1.13%, 16.26%) and 12.15% (95% CI 4.35%, 20.53%) increases in mtDNAcn, respectively. The dose-response trend with statistical significance was observed across tertiles of DMA and TAs in the third trimester with mtDNAcn (DMA percent changes (%Δ) = 25.60 (95% CI 6.73, 47.82), for the highest vs the lowest tertile (P = 0.02); TAs %Δ = 40.31 (95% CI 19.25, 65.10), for the highest vs the lowest tertile (P = 0.0002)). These findings may prove the relationships between prenatal arsenic species levels and neonatal mitochondrial dysfunction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s11356-024-32933-7Test; https://pubmed.ncbi.nlm.nih.gov/38789711Test |
| DOI: | 10.1007/s11356-024-32933-7 |
| الإتاحة: | https://doi.org/10.1007/s11356-024-32933-7Test https://pubmed.ncbi.nlm.nih.gov/38789711Test |
| حقوق: | © 2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. |
| رقم الانضمام: | edsbas.C75F0721 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s11356-024-32933-7 |
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