دورية أكاديمية
Purkinje cell dysfunction causes disrupted sleep in ataxic mice.
| العنوان: | Purkinje cell dysfunction causes disrupted sleep in ataxic mice. |
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| المؤلفون: | Salazar Leon, Luis E, Brown, Amanda M, Kaku, Heet, Sillitoe, Roy V |
| المصدر: | Dis Model Mech ; ISSN:1754-8411 ; Volume:17 ; Issue:6 |
| بيانات النشر: | Silverchair Information Systems |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Ataxia, Cerebellar nuclei, Circadian rhythms, Purkinje cells, Sleep |
| الوصف: | Purkinje cell dysfunction disrupts movement and causes disorders such as ataxia. Recent evidence suggests that Purkinje cell dysfunction may also alter sleep regulation. Here, we used an ataxic mouse model generated by silencing Purkinje cell neurotransmission (L7Cre;Vgatfx/fx) to better understand how cerebellar dysfunction impacts sleep physiology. We focused our analysis on sleep architecture and electrocorticography (ECoG) patterns based on their relevance to extracting physiological measurements during sleep. We found that circadian activity was unaltered in the mutant mice, although their sleep parameters and ECoG patterns were modified. The L7Cre;Vgatfx/fx mutant mice had decreased wakefulness and rapid eye movement (REM) sleep, whereas non-REM sleep was increased. The mutants had an extended latency to REM sleep, which is also observed in human patients with ataxia. Spectral analysis of ECoG signals revealed alterations in the power distribution across different frequency bands defining sleep. Therefore, Purkinje cell dysfunction may influence wakefulness and equilibrium of distinct sleep stages in ataxia. Our findings posit a connection between cerebellar dysfunction and disrupted sleep and underscore the importance of examining cerebellar circuit function in sleep disorders. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1242/dmm.050379Test; https://pubmed.ncbi.nlm.nih.gov/38563553Test |
| DOI: | 10.1242/dmm.050379 |
| الإتاحة: | https://doi.org/10.1242/dmm.050379Test https://pubmed.ncbi.nlm.nih.gov/38563553Test |
| حقوق: | © 2024. Published by The Company of Biologists Ltd. |
| رقم الانضمام: | edsbas.D3FC8869 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1242/dmm.050379 |
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