مراجعة
Translation of cell therapies to treat autoimmune disorders.
| العنوان: | Translation of cell therapies to treat autoimmune disorders. |
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| المؤلفون: | Mehta, Jinal M, Hiremath, Shivani C, Chilimba, Chishiba, Ghasemi, Azin, Weaver, Jessica D |
| المصدر: | Adv Drug Deliv Rev ; ISSN:1872-8294 ; Volume:205 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Autoimmune disease, Cell therapy, Cell therapy translation, Regenerative medicine |
| الوصف: | Autoimmune diseases are a diverse and complex set of chronic disorders with a substantial impact on patient quality of life and a significant global healthcare burden. Current approaches to autoimmune disease treatment comprise broadly acting immunosuppressive drugs that lack disease specificity, possess limited efficacy, and confer undesirable side effects. Additionally, there are limited treatments available to restore organs and tissues damaged during the course of autoimmune disease progression. Cell therapies are an emergent area of therapeutics with the potential to address both autoimmune disease immune dysfunction as well as autoimmune disease-damaged tissue and organ systems. In this review, we discuss the pathogenesis of common autoimmune disorders and the state-of-the-art in cell therapy approaches to (1) regenerate or replace autoimmune disease-damaged tissue and (2) eliminate pathological immune responses in autoimmunity. Finally, we discuss critical considerations for the translation of cell products to the clinic. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.addr.2023.115161Test; https://pubmed.ncbi.nlm.nih.gov/38142739Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843859Test/ |
| DOI: | 10.1016/j.addr.2023.115161 |
| الإتاحة: | https://doi.org/10.1016/j.addr.2023.115161Test https://pubmed.ncbi.nlm.nih.gov/38142739Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10843859Test/ |
| حقوق: | Copyright © 2023 Elsevier B.V. All rights reserved. |
| رقم الانضمام: | edsbas.3F1A648C |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.addr.2023.115161 |
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