دورية أكاديمية
Effect of RAS and BRAF mutations on peritoneal metastasis risk and cytoreductive surgery/hyperthermic intraperitoneal chemotherapy efficacy in colorectal cancer: A systematic review and meta-analysis.
| العنوان: | Effect of RAS and BRAF mutations on peritoneal metastasis risk and cytoreductive surgery/hyperthermic intraperitoneal chemotherapy efficacy in colorectal cancer: A systematic review and meta-analysis. |
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| المؤلفون: | Gao, Ziming, Qi, Xiang, Wang, Ruiying, Wen, Zhitong, Qi, Hao, Ju, Mingguang, Liu, Xiaoxu, Wang, Junye, Zhou, Heng, Zhu, Zhi, Liu, Xiaofang, Li, Kai |
| المصدر: | Eur J Surg Oncol ; ISSN:1532-2157 ; Volume:50 ; Issue:9 |
| بيانات النشر: | Elsevier Science |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | BRAF, CRS/HIPEC, Colorectal cancer, Peritoneal metastasis, RAS |
| الوصف: | Colorectal cancer (CRC) patients with peritoneal metastasis (CRC-PM) have a worse prognosis than those with liver and lung metastases. Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is an effective locoregional treatment for CRC-PM. To date, the prognostic analysis of CRS/HIPEC mostly focuses on clinical and pathological characteristics; however, genetic characteristics, such as RAS/BRAF mutation status, are not sufficient. This study aimed to systematically assess the correlation between RAS/BRAF status and PM risk, as well as the prognostic efficacy of CRS/HIPEC for CRC. |
| نوع الوثيقة: | article in journal/newspaper review |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1016/j.ejso.2024.108474Test; https://pubmed.ncbi.nlm.nih.gov/38870874Test |
| DOI: | 10.1016/j.ejso.2024.108474 |
| الإتاحة: | https://doi.org/10.1016/j.ejso.2024.108474Test https://pubmed.ncbi.nlm.nih.gov/38870874Test |
| حقوق: | Copyright © 2024. Published by Elsevier Ltd. |
| رقم الانضمام: | edsbas.E43D799B |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.ejso.2024.108474 |
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