دورية أكاديمية
Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework
| العنوان: | Validation of the Remote Automated ki:e Speech Biomarker for Cognition in Mild Cognitive Impairment: Verification and Validation following DiME V3 Framework |
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| المؤلفون: | Tröger, Johannes, Baykara, Ebru, Zhao, Jian, ter Huurne, Daphne, Possemis, Nina, Mallick, Elisa, Schäfer, Simona, Schwed, Louisa, Mina, Mario, Linz, Nicklas, Ramakers, Inez, Ritchie, Craig |
| المصدر: | http://lobid.org/resources/99370675877106441Test#!, 6(3):107-116. |
| سنة النشر: | 2022 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Dementia, Clinical trials, Speech biomarker, Speech analysis, Digital biomarker, Mild cognitive impairment, Validation – Research Article |
| الوصف: | Introduction!#!Progressive cognitive decline is the cardinal behavioral symptom in most dementia-causing diseases such as Alzheimer's disease. While most well-established measures for cognition might not fit tomorrow's decentralized remote clinical trials, digital cognitive assessments will gain importance. We present the evaluation of a novel digital speech biomarker for cognition (SB-C) following the Digital Medicine Society's V3 framework: verification, analytical validation, and clinical validation.!##!Methods!#!Evaluation was done in two independent clinical samples: the Dutch DeepSpA (!##!Results!#!Verification!##!Conclusion!#!Our results suggest that the ki:e SB-C is an objective, scalable, and reliable indicator of cognitive decline, fit for purpose as a remote assessment in clinical early dementia trials. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| العلاقة: | https://repository.publisso.de/resource/frl:6440971Test; https://doi.org/10.1159/000526471Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710455Test/ |
| DOI: | 10.1159/000526471 |
| الإتاحة: | https://doi.org/10.1159/000526471Test https://repository.publisso.de/resource/frl:6440971Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9710455Test/ |
| حقوق: | https://creativecommons.org/licenses/by-nc/4.0Test/ |
| رقم الانضمام: | edsbas.79D6DEFF |
| قاعدة البيانات: | BASE |
| DOI: | 10.1159/000526471 |
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