دورية أكاديمية
Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors
| العنوان: | Sex Differences in Outcome After Thrombectomy for Acute Ischemic Stroke are Explained by Confounding Factors |
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| المؤلفون: | Deb-Chatterji, Milani, Schlemm, Eckhard, Flottmann, Fabian, Meyer, Lukas, Alegiani, Anna, Brekenfeld, Caspar, Fiehler, Jens, Gerloff, Christian, Thomalla, Götz, Gerloff, C., Fiehler, J., Thomalla, G., Alegiani, A., Boeckh-Behrens, Wunderlich, Silke, Ernemann, Ulrike, Poli, Sven, Siebert, Eberhard, Nolte, Christian H., Zweynert, Sarah, Bohner, Georg, Ludolph, Alexander, Henn, Karl-Heinz, Pfeilschifter, Waltraud, Keil, Fee, Röther, Joachim, Eckert, Bernd, Berrouschot, Jörg, Bormann, Albrecht, Solymosi, László, Petzold, Gabor, Kraemer, Christoffer, Dichgans, Martin, Tiedt, Steffen, Kellert, Lars, Dorn, Franziska, Petersen, Martina, Stögbauer, Florian, Braun, Michael, Hamann, Gerhard F., Gröschel, Klaus, Uphaus, Timo |
| المصدر: | http://lobid.org/resources/99370677150706441Test#!, 31(4):1101-1109. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Brain Ischemia/surgery [MeSH], Female [MeSH], Thrombectomy [MeSH], Aged [MeSH], Humans [MeSH], Prospective Studies [MeSH], Treatment Outcome [MeSH], Angiography, Retrospective Studies [MeSH], Gender difference, Intervention, Original Article, Stroke/surgery [MeSH], Ischemic Stroke [MeSH], Ischemia, Male [MeSH], Outcome predictors, Sex Characteristics [MeSH], Endovascular Procedures [MeSH] |
| الوصف: | Purpose!#!The aim of this study was to analyze sex differences in outcome after thrombectomy for acute ischemic stroke in clinical practice in a large prospective multicenter registry.!##!Methods!#!Data of consecutive stroke patients treated with thrombectomy (June 2015-April 2018) derived from an industry-independent registry (German Stroke Registry-Endovascular Treatment) were prospectively analyzed. Multivariable binary logistic regression analyses were applied to determine whether sex is a predictor of functional independence outcome (defined as a modified Rankin scale [mRS] 0-2) 90 days after stroke.!##!Results!#!In total, 2316 patients were included in the analysis, 1170 (50.5%) were female and 1146 (49.5%) were male. Women were older (median age 78 vs. 72 years; p < 0.001) and more frequently had a prestroke functional impairment defined by mRS >1 (24.8% vs. 14.1%; p < 0.001). In unadjusted analyses, independent outcome at 90 days was less frequent in women (33.2%) than men (40.6%; p < 0.001). Likewise, mortality was higher in women than in men (30.7% vs. 26.4%; p = 0.024). In adjusted regression analyses, however, sex was not associated with outcome. Lower age, a lower baseline National Institutes of Health Stroke Scale score, a higher Alberta Stroke Program Early CT score, prestroke functional independence, successful reperfusion, and concomitant intravenous thrombolysis therapy predicted independent outcome.!##!Conclusion!#!Women showed a worse functional outcome after thrombectomy for acute ischemic stroke in clinical practice; however, after adjustment for crucial confounders sex was not a predictor of outcome. The difference in outcome thus appears to result from differences in confounding factors such as age and prestroke functional status. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-9937-0-6771-3 9937-0-6771-5 |
| العلاقة: | https://repository.publisso.de/resource/frl:6441921Test; https://doi.org/10.1007/s00062-020-00983-2Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648700Test/ |
| DOI: | 10.1007/s00062-020-00983-2 |
| الإتاحة: | https://doi.org/10.1007/s00062-020-00983-2Test https://repository.publisso.de/resource/frl:6441921Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8648700Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.BC1D4DDF |
| قاعدة البيانات: | BASE |
| ردمك: | 9789937067713 9937067715 |
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| DOI: | 10.1007/s00062-020-00983-2 |