دورية أكاديمية
Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination
| العنوان: | Lack of astrocytes hinders parenchymal oligodendrocyte precursor cells from reaching a myelinating state in osmolyte-induced demyelination |
|---|---|
| المؤلفون: | Lohrberg, Melanie, Winkler, Anne, Franz, Jonas, van der Meer, Franziska, Ruhwedel, Torben, Sirmpilatze, Nikoloz, Dadarwal, Rakshit, Handwerker, Ronja, Esser, Daniel, Wiegand, Kerstin, Hagel, Christian, Gocht, Andreas, König, Fatima Barbara, Boretius, Susann, Möbius, Wiebke, Stadelmann, Christine, Barrantes-Freer, Alonso |
| المصدر: | http://lobid.org/resources/99370678498306441Test#!, 8(1):224. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Aged [MeSH], Demyelinating Diseases/metabolism [MeSH], Myelinolysis, Central Pontine/pathology [MeSH], Remyelination, Neural Stem Cells [MeSH], Antidiuretic Agents [MeSH], Astrocytes/pathology [MeSH], Sodium Chloride [MeSH], Cell Differentiation [MeSH], Astrocytes, Myelin Sheath [MeSH], Lateral Ventricles/metabolism [MeSH], Male [MeSH], Oligodendrocyte Precursor Cells/physiology [MeSH], Cell Lineage [MeSH], Disease Models, Animal [MeSH], Oligodendrocyte Precursor Cells/metabolism [MeSH], Deamino Arginine Vasopressin [MeSH], Central Pontine/chemically induced [MeSH], Female [MeSH], Neoplasm Proteins/metabolism [MeSH], Adult [MeSH], Humans [MeSH], Nestin/metabolism [MeSH], Neural stem cells, Rats [MeSH], Middle Aged [MeSH], Oligodendroglia/metabolism [MeSH] |
| الوصف: | Demyelinated lesions in human pons observed after osmotic shifts in serum have been referred to as central pontine myelinolysis (CPM). Astrocytic damage, which is prominent in neuroinflammatory diseases like neuromyelitis optica (NMO) and multiple sclerosis (MS), is considered the primary event during formation of CPM lesions. Although more data on the effects of astrocyte-derived factors on oligodendrocyte precursor cells (OPCs) and remyelination are emerging, still little is known about remyelination of lesions with primary astrocytic loss. In autopsy tissue from patients with CPM as well as in an experimental model, we were able to characterize OPC activation and differentiation. Injections of the thymidine-analogue BrdU traced the maturation of OPCs activated in early astrocyte-depleted lesions. We observed rapid activation of the parenchymal NG2 |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6452322Test; https://doi.org/10.1186/s40478-020-01105-2Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761156Test/ |
| DOI: | 10.1186/s40478-020-01105-2 |
| الإتاحة: | https://doi.org/10.1186/s40478-020-01105-2Test https://repository.publisso.de/resource/frl:6452322Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7761156Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.7561FED |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s40478-020-01105-2 |
|---|