دورية أكاديمية
Coexistence of diffuse panbronchiolitis and sarcoidosis revealed during splenectomy: a case report
| العنوان: | Coexistence of diffuse panbronchiolitis and sarcoidosis revealed during splenectomy: a case report |
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| المؤلفون: | Akaba, Tomohiro, Takeyama, Kiyoshi, Kondo, Mitsuko, Kobayashi, Fumi, Okabayashi, Asako, Sawada, Tatsuo, Tagaya, Etsuko |
| المصدر: | BMC pulmonary medicine, 20:77 |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Diffuse panbronchiolitis, CD4/CD8 ratio, Sarcoidosis, Splenectomy |
| الوصف: | BACKGROUND: Sarcoidosis is a systemic granulomatous disease caused by CD4+ cell-dominant inflammation. Meanwhile, diffuse panbronchiolitis is a chronic inflammatory respiratory disease predominantly caused by CD8+ lymphocytes and neutrophils. Herein, we report a rare case of sarcoidosis in which the clinical presentation had become evident as diffuse panbronchiolitis after splenectomy for sarcoidosis. CASE PRESENTATION: A 23-year-old Japanese woman was referred to our hospital due to splenomegaly of unknown etiology. Upon admission, chest computed tomography scan revealed centrilobular and randomly distributed small nodules in both lungs. Bronchoalveolar lavage revealed a high proportion of lymphocytes and a decreased CD4/CD8 ratio. However, the biopsy specimens obtained from both the liver and lungs revealed noncaseating epithelioid granulomas, which confirmed the diagnosis of sarcoidosis. The patient underwent splenectomy due to progressive cytopenia and high risk of splenic rupture. After the surgery, the condition of the patient was consistently good for 3 months. Then, she gradually developed productive cough and dyspnea. Both sinus and chest computed tomography scan revealed chronic paranasal sinusitis and deterioration of centrilobular nodules in both lung fields, respectively. The second bronchoalveolar lavage revealed a high proportion of neutrophils, and the bronchoalveolar lavage fluid tested positive for Hemophilus influenzae. The titer of cold agglutinin was elevated, thereby confirming the diagnosis of diffuse panbronchiolitis. On the basis of the clinical and radiological findings, the condition of the patient improved with low-dose macrolide therapy for 3 months. CONCLUSIONS: The coexistence of sarcoidosis and diffuse panbronchiolitis has not been previously reported, and the hidden profiles of diffuse panbronchiolitis may have been revealed by splenectomy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6423796Test; https://doi.org/10.1186/s12890-020-1117-yTest; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106566Test/ |
| DOI: | 10.1186/s12890-020-1117-y |
| الإتاحة: | https://doi.org/10.1186/s12890-020-1117-yTest https://repository.publisso.de/resource/frl:6423796Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7106566Test/ |
| حقوق: | http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.EE5A1196 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1186/s12890-020-1117-y |
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