دورية أكاديمية
Cell protrusions and contractions generate long-range membrane tension propagation
| العنوان: | Cell protrusions and contractions generate long-range membrane tension propagation |
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| المؤلفون: | De Belly, Henry, Yan, Shannon, Borja da Rocha, Hudson, Ichbiah, Sacha, Town, Jason P., Zager, Patrick J., Estrada, Dorothy C., Meyer, Kirstin, Turlier, Hervé, Bustamante, Carlos, Weiner, Orion D. |
| المصدر: | http://lobid.org/resources/990110451790206441Test#!, 186(14):3049-3061. |
| سنة النشر: | 2023 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | optical tweezers, cell mechanics, membrane tension, cell migration, actomyosin contractility, cell protrusion, cell cortex, optogenetics, cell polarity, actin cytoskeleton |
| الوصف: | Membrane tension is thought to be a long-range integrator of cell physiology. Membrane tension has been proposed to enable cell polarity during migration through front-back coordination and long-range protrusion competition. These roles necessitate effective tension transmission across the cell. However, conflicting observations have left the field divided as to whether cell membranes support or resist tension propagation. This discrepancy likely originates from the use of exogenous forces that may not accurately mimic endogenous forces. We overcome this complication by leveraging optogenetics to directly control localized actin-based protrusions or actomyosin contractions while simultaneously monitoring the propagation ofmembrane tension using dual-trap optical tweezers. Surprisingly, actin-driven protrusions and actomyosin contractions both elicit rapid global membrane tension propagation, whereas forces applied to cell membranes alone do not. We present a simple unifying mechanical model in which mechanical forces that engage the actin cortex drive rapid, robust membrane tension propagation through long-range membrane flows. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6453512Test; https://doi.org/10.1016/j.cell.2023.05.014Test; https://www.cell.com/cell/fulltext/S0092-8674Test(23)00533-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423005330%3Fshowall%3Dtrue#supplementaryMaterial |
| DOI: | 10.1016/j.cell.2023.05.014 |
| الإتاحة: | https://doi.org/10.1016/j.cell.2023.05.014Test https://repository.publisso.de/resource/frl:6453512Test https://www.cell.com/cell/fulltext/S0092-8674Test(23)00533-0?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867423005330%3Fshowall%3Dtrue#supplementaryMaterial |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.904A57F9 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1016/j.cell.2023.05.014 |
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