دورية أكاديمية
Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis
| العنوان: | Single-cell transcriptomics and epigenomics unravel the role of monocytes in neuroblastoma bone marrow metastasis |
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| المؤلفون: | Fetahu, Irfete, Esser-Skala, Wolfgang, Dnyansagar, Rohit, Sindelar, Samuel, Rifatbegovic, Fikret, Bileck, Andrea, Skos, Lukas, Bozsaky, Eva, Lazic, Daria, Shaw, Lisa, Toetzl, Marcus, Tarlungeanu, Dora, Bernkopf, Marie, Rados, Magdalena, Weninger, Wolfgang, Tomazou, Eleni Marina, Bock, Christoph, Gerner, Christopher, Ladenstein, Ruth, Farlik, Matthias, Fortelny, Nikolaus, Taschner-Mandl, Sabine |
| المصدر: | Nature Communications, 14(1):3620 |
| سنة النشر: | 2023 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Epigenetics, Cancer genetics, Chromatin structure, Transcriptomics, Cancer microenvironment |
| الوصف: | Metastasis is the major cause of cancer-related deaths. Neuroblastoma (NB), a childhood tumor has been molecularly defined at the primary cancer site, however, the bone marrow (BM) as the metastatic niche of NB is poorly characterized. Here we perform single-cell transcriptomic and epigenomic profiling of BM aspirates from 11 subjects spanning three major NB subtypes and compare these to five age-matched and metastasis-free BM, followed by in-depth single cell analyses of tissue diversity and cell-cell interactions, as well as functional validation. We show that cellular plasticity of NB tumor cells is conserved upon metastasis and tumor cell type composition is NB subtype-dependent. NB cells signal to the BM microenvironment, rewiring via macrophage mgration inhibitory factor and midkine signaling specifically monocytes, which exhibit M1 and M2 features, are marked by activation of pro- and anti-inflammatory programs, and express tumor-promoting factors, reminiscent of tumor-associated macrophages. The interactions and pathways characterized in our study provide the basis for therapeutic approaches that target tumor-to-microenvironment interactions. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6461965Test; https://doi.org/10.1038/s41467-023-39210-0Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293285Test/; https://www.nature.com/articles/s41467-023-39210-0#Sec41Test |
| DOI: | 10.1038/s41467-023-39210-0 |
| الإتاحة: | https://doi.org/10.1038/s41467-023-39210-0Test https://repository.publisso.de/resource/frl:6461965Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10293285Test/ https://www.nature.com/articles/s41467-023-39210-0#Sec41Test |
| حقوق: | CC BY 4.0 |
| رقم الانضمام: | edsbas.A5DC1FA2 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1038/s41467-023-39210-0 |
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