دورية أكاديمية
Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring—the heart as a target for fetal programming in rats
| العنوان: | Diabetic pregnancy as a novel risk factor for cardiac dysfunction in the offspring—the heart as a target for fetal programming in rats |
|---|---|
| المؤلفون: | Schütte, Till, Kedziora, Sarah, Haase, Nadine, Herse, Florian, Alenina, Natalia, Muller, Dominik N, Bader, Michael, Schupp, Michael, Dechend, Ralf, Golic, Michaela, Kräker, Kristin |
| المصدر: | http://lobid.org/resources/99370676916506441Test#!, 64(12):2829-2842. |
| سنة النشر: | 2021 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | Fetal Development [MeSH], Rats, Sprague-Dawley [MeSH], Risk Factors [MeSH], Echocardiography, Maternal inheritance, Heart Diseases [MeSH], Male [MeSH], Diabetes Mellitus, Type 2/genetics [MeSH], Cardiovascular diseases, Diet, High-Fat/adverse effects [MeSH], Female [MeSH], Myocytes, Cardiac [MeSH], Pregnancy, Rats [MeSH], Prenatal Exposure Delayed Effects [MeSH], Animals [MeSH], Infant, High-fat, Article, Transgenic, Hyperglycaemia, Pregnancy [MeSH] |
| الوصف: | Aims/hypothesis!#!The impact of diabetic pregnancy has been investigated extensively regarding offspring metabolism; however, little is known about the influence on the heart. We aimed to characterise the effects of a diabetic pregnancy on male adult offspring cardiac health after feeding a high-fat diet in an established transgenic rat model.!##!Methods!#!We applied our rat model for maternal type 2 diabetes characterised by maternal insulin resistance with hyperglycaemia and hyperinsulinaemia. Diabetes was induced preconceptionally via doxycycline-induced knock down of the insulin receptor in transgenic rats. Male wild-type offspring of diabetic and normoglycaemic pregnancies were raised by foster mothers, followed up into adulthood and subgroups were challenged by a high-fat diet. Cardiac phenotype was assessed by innovative speckle tracking echocardiography, circulating factors, immunohistochemistry and gene expression in the heart.!##!Results!#!When feeding normal chow, we did not observe differences in cardiac function, gene expression and plasma brain natriuretic peptide between adult diabetic or normoglycaemic offspring. Interestingly, when being fed a high-fat diet, adult offspring of diabetic pregnancy demonstrated decreased global longitudinal (-14.82 ± 0.59 vs -16.60 ± 0.48%) and circumferential strain (-23.40 ± 0.57 vs -26.74 ± 0.34%), increased relative wall thickness (0.53 ± 0.06 vs 0.37 ± 0.02), altered cardiac gene expression, enlarged cardiomyocytes (106.60 ± 4.14 vs 87.94 ± 1.67 μm), an accumulation of immune cells in the heart (10.27 ± 0.30 vs 6.48 ± 0.48 per fov) and higher plasma brain natriuretic peptide levels (0.50 ± 0.12 vs 0.12 ± 0.03 ng/ml) compared with normoglycaemic offspring on a high-fat diet. Blood pressure, urinary albumin, blood glucose and body weight were unaltered between groups on a high-fat diet.!##!Conclusions/interpretation!#!Diabetic pregnancy in rats induces cardiac dysfunction, left ventricular hypertrophy and altered proinflammatory status in adult offspring only ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6451896Test; https://doi.org/10.1007/s00125-021-05566-5Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563640Test/ |
| DOI: | 10.1007/s00125-021-05566-5 |
| الإتاحة: | https://doi.org/10.1007/s00125-021-05566-5Test https://repository.publisso.de/resource/frl:6451896Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8563640Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.FD2F4230 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00125-021-05566-5 |
|---|