دورية أكاديمية
Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels
| العنوان: | Intravascular adhesion and recruitment of neutrophils in response to CXCL1 depends on their TRPC6 channels |
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| المؤلفون: | Lindemann, Otto, Rossaint, Jan, Najder, Karolina, Schimmelpfennig, Sandra, Hofschröer, Verena, Wälte, Mike, Fels, Benedikt, Oberleithner, Hans, Zarbock, Alexander, Schwab, Albrecht |
| المصدر: | http://lobid.org/resources/99370678534106441Test#!, 98(3):349-360. |
| سنة النشر: | 2020 |
| المجموعة: | Publisso (ZB MED-Publikationsportal Lebenswissenschaften) |
| مصطلحات موضوعية: | CXCR2, TRPC6 channel, Calcium/metabolism [MeSH], Kidney/immunology [MeSH], Mice, Inbred C57BL [MeSH], Cell Adhesion [MeSH], Neutrophil recruitment, Kidney/metabolism [MeSH], Reperfusion Injury/metabolism [MeSH], Chemokine CXCL1/immunology [MeSH], Neutrophils/physiology [MeSH], Animals [MeSH], TRPC6 Cation Channel/immunology [MeSH], Knockout [MeSH], Original Article, Mice [MeSH], Kidney Diseases/immunology [MeSH], Chemotaxis [MeSH], Reperfusion Injury/immunology [MeSH], Kidney Diseases/metabolism [MeSH], CXCL1 |
| الوصف: | Here we report a novel role for TRPC6, a member of the transient receptor potential (TRPC) channel family, in the CXCL1-dependent recruitment of murine neutrophil granulocytes. Representing a central element of the innate immune system, neutrophils are recruited from the blood stream to a site of inflammation. The recruitment process follows a well-defined sequence of events including adhesion to the blood vessel walls, migration, and chemotaxis to reach the inflammatory focus. A common feature of the underlying signaling pathways is the utilization of Ca |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://repository.publisso.de/resource/frl:6441541Test; https://doi.org/10.1007/s00109-020-01872-4Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080674Test/ |
| DOI: | 10.1007/s00109-020-01872-4 |
| الإتاحة: | https://doi.org/10.1007/s00109-020-01872-4Test https://repository.publisso.de/resource/frl:6441541Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7080674Test/ |
| حقوق: | https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.E35D133D |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00109-020-01872-4 |
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