التفاصيل البيبلوغرافية
| العنوان: |
Ras-dependent and -independent pathways target the mitogen-activated protein kinase network in macrophages |
| المؤلفون: |
Büscher, D., Hipskind, R.A., Krautwald, S., Reimann, T., Baccarini, M. |
| سنة النشر: |
1995 |
| المجموعة: |
Publikationsdatenbank der Fraunhofer-Gesellschaft |
| مصطلحات موضوعية: |
amino acid, biochemistry, cell line, DNA binding protein, enzyme activation, growth factor, guanosine triphosphatase, macrophage, molecular biology, mouse, phosphorylation, protein kinase |
| الوقت: |
615, 610, 620, 572 |
| الوصف: |
S.466-475 ; Mitogen-activated protein kinases (MAPKs) are activated upon a variety of extracellular stimuli in different cells. In macrophages, colony-stimulating factor 1 (CSF-1) stimulates proliferation, while bacterial lipopolysaccharide (LPS) inhibits cell growth and causes differentiation and activation. Both CSF-1 and LPS rapidly activate the MAPK network and induce the phosphorylation of two distinct ternary complex factors (TCFs), TCF/Elk and TCF/SAP. CSF-1, but not LPS, stimulated the formation of p21ras. GTP complexes. Expression of a dominant negative ras mutant reduced, but did not abolish, CSF-1-mediated stimulation of MEK and MAPK. In contrast, activation of the MEK kinase Raf-1 was Ras independent. Treatment with the phosphatidylcholine-specific phospholipase C inhibitor D609 suppressed LPS-mediated, but not CSF-1-mediated, activation of Raf-1, MEK, and MAPK. Similarly, down-regulation or inhibition of protein kinase C blocked MEK and MAPK induction by LPS. ; 15 ; Nr.1 |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| العلاقة: |
Molecular and Cellular Biology; https://publica.fraunhofer.de/handle/publica/186974Test |
| الإتاحة: |
https://publica.fraunhofer.de/handle/publica/186974Test |
| رقم الانضمام: |
edsbas.FF06FE9D |
| قاعدة البيانات: |
BASE |
