دورية أكاديمية
Mouse Organ-Specific Proteins and Functions.
| العنوان: | Mouse Organ-Specific Proteins and Functions. |
|---|---|
| المؤلفون: | Sun, Bingyun, Lorang, Cynthia, Qin, Shizhen, Zhang, Yijuan, Liu, Ken, Li, Gray, Sun, Zhi, Francke, Ashley, Utleg, Angelita G, Hu, Zhiyuan, Wang, Kai, Moritz, Robert L, Hood, Leroy |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence St. Joseph Health Digital Commons |
| سنة النشر: | 2021 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | washington, seattle, isb, Animals, Genetic Variation, Humans, Mice, Organ Specificity, Proteins, Proteome, Proteomics, Genetics and Genomics |
| الوصف: | Organ-specific proteins (OSPs) possess great medical potential both in clinics and in biomedical research. Applications of them-such as alanine transaminase, aspartate transaminase, and troponins-in clinics have raised certain concerns of their organ specificity. The dynamics and diversity of protein expression in heterogeneous human populations are well known, yet their effects on OSPs are less addressed. Here, we used mice as a model and implemented a breadth study to examine the panorgan proteome for potential variations in organ specificity in different genetic backgrounds. Using reasonable resources, we generated panorgan proteomes of four in-bred mouse strains. The results revealed a large diversity that was more profound among OSPs than among proteomes overall. We defined a robustness score to quantify such variation and derived three sets of OSPs with different stringencies. In the meantime, we found that the enriched biological functions of OSPs are also organ-specific and are sensitive and useful to assess the quality of OSPs. We hope our breadth study can open doors to explore the molecular diversity and dynamics of organ specificity at the protein level. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.psjhealth.org/publications/5577Test; https://pubmed.ncbi.nlm.nih.gov/34943957Test |
| الإتاحة: | https://digitalcommons.psjhealth.org/publications/5577Test https://pubmed.ncbi.nlm.nih.gov/34943957Test |
| رقم الانضمام: | edsbas.E220753F |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |