دورية أكاديمية
Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection.
| العنوان: | Angiotensin II receptor I auto-antibodies following SARS-CoV-2 infection. |
|---|---|
| المؤلفون: | Jiang, Yonghou, Duffy, Fergal, Hadlock, Jennifer J, Raappana, Andrew, Styrchak, Sheila, Beck, Ingrid, Mast, Fred D, Miller, Leslie R, Chour, William, Houck, John, Armistead, Blair, Duvvuri, Venkata R, Yeung, Winnie, Haglund, Micaela, Wallner, Jackson, Wallick, Julie A, Hardy, Samantha, Oldroyd, Alyssa, Ko, Daisy, Gervassi, Ana, Murray, Kim M, Kaplan, Henry G, Aitchison, John D, Heath, James R, Sather, D Noah, Goldman, Jason D, Frenkel, Lisa, Harrington, Whitney E |
| المصدر: | Articles, Abstracts, and Reports |
| بيانات النشر: | Providence St. Joseph Health Digital Commons |
| سنة النشر: | 2021 |
| المجموعة: | Providence St. Joseph Health Digital Commons |
| مصطلحات موضوعية: | washington, seattle, isb, system, Adult, COVID-19, Graft Rejection, Humans, Kidney Transplantation, Male, Middle Aged, Receptor, Angiotensin, Type 1, Infectious Disease, Systems Biology |
| الوصف: | BACKGROUND: Coronavirus disease 2019 (COVID-19) is associated with endothelial activation and coagulopathy, which may be related to pre-existing or infection-induced pro-thrombotic autoantibodies such as those targeting angiotensin II type I receptor (AT1R-Ab). METHODS: We compared prevalence and levels of AT1R-Ab in COVID-19 cases with mild or severe disease to age and sex matched negative controls utilizing multivariate logistic and quantile regression adjusted for comorbidities including hypertension, diabetes, and heart disease. RESULTS: There were trends toward increased prevalence (50% vs. 33%, p = 0.1) and level of AT1R-Ab (median 9.8 vs. 6.1 U/mL, p = 0.06) in all cases versus controls. When considered by COVID-19 disease severity, there was a trend toward increased prevalence of AT1R-Ab (55% vs. 31%, p = 0.07), as well as significantly higher AT1R-Ab levels (median 10.7 vs. 5.9 U/mL, p = 0.03) amongst individuals with mild COVID-19 versus matched controls. In contrast, the prevalence (42% vs. 37%, p = 0.9) and level (both medians 6.7 U/mL, p = 0.9) of AT1R-Ab amongst those with severe COVID-19 did not differ from matched controls. CONCLUSIONS: These findings support an association between COVID-19 and AT1R-Ab, emphasizing that vascular pathology may be present in individuals with mild COVID-19 as well as those with severe disease. |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://digitalcommons.psjhealth.org/publications/5602Test; https://pubmed.ncbi.nlm.nih.gov/34788328Test/ |
| الإتاحة: | https://digitalcommons.psjhealth.org/publications/5602Test https://pubmed.ncbi.nlm.nih.gov/34788328Test/ |
| رقم الانضمام: | edsbas.B6BFB808 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |