دورية أكاديمية
Effects of methanol extracts of insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats
| العنوان: | Effects of methanol extracts of insulin leaves (Tithonia diversifolia (hemsl.) A. Gray) on insulin resistance and secretion of alloxan induced-obese diabetic rats |
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| المؤلفون: | Fitriyanto, Raden Edi, Sugiarto, Sugiarto, Ardiyanto, Dwi Tonang |
| المصدر: | Jurnal Kedokteran dan Kesehatan Indonesia; JKKI, Vol 11, No 2, (2020); 180-190 ; 2527-2950 ; 2085-4145 |
| بيانات النشر: | Faculty of Medicine, Universitas Islam Indonesia |
| سنة النشر: | 2020 |
| المجموعة: | Portal Journal Universitas Islam Indonesia |
| مصطلحات موضوعية: | Obesity, diabetes mellitus, Tithonia diversifolia (Hemsl.) A. Gray, Wistar rats, HOMA-IR index, HOMA-B index, insulin resistance, insulin secretion |
| الوصف: | Background: Obesity can lead to insulin resistance contributing to diabetes mellitus (DM). Empirically, insulin leaves of Tithonia diversifolia (Hems.) A. Gray (Td) can be used as a traditional DM medicine.Objective: This study aims to determine effects of Td methanol extracts on insulin resistance and secretion in DM rats induced by a high-fat diet and alloxan.Methods: This study was a randomized pre and post-test control group. Its research subjects were divided into five groups: a normal group, an obese group with diabetes without therapy (KN), an obese group with DM treated by the Td extracts with a dose 50 mg/kg, 250 mg/kg, and 500 mg/kg. The DM obesity was induced by a high-fat diet followed by administration of alloxan with a dose of 135 mg/kg intraperitoneally. The Td extracts was administered after 7 days of DM induction by using gastric swabs. Insulin resistance in the rats was measured based on HOMA-IR index values, while their insulin secretion was based on HOMA-B values. A statistical analysis was conducted by a 95% confidence level.Results: Blood glucose levels decreased to normal levels in all the groups administered by the Td extracts, except in the KN group. The HOMA-IR index values in all groups treated by the Td extracts did not increase except in the KN group. The HOMA-B index values in groups with doses of 50 and 250 mg/kgBW experienced a higher increase and significantly differed with the KN group.Conclusion: The administration of the Td extracts with doses of 50 and 250 mg/ kgBW in the DM rats could decrease blood glucose levels, could prevent insulin resistance and could increase insulin secretion. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://journal.uii.ac.id/JKKI/article/view/3422/pdfTest; https://journal.uii.ac.id/JKKI/article/downloadSuppFile/3422/2451Test; https://journal.uii.ac.id/JKKI/article/downloadSuppFile/3422/2452Test; https://journal.uii.ac.id/JKKI/article/downloadSuppFile/3422/2453Test; https://journal.uii.ac.id/JKKI/article/downloadSuppFile/3422/2454Test; https://journal.uii.ac.id/JKKI/article/view/3422Test |
| DOI: | 10.20885/JKKI.Vol11.Iss2.art11 |
| الإتاحة: | https://doi.org/10.20885/JKKI.Vol11.Iss2.art11Test https://journal.uii.ac.id/JKKI/article/view/3422Test |
| حقوق: | Copyright (c) 2020 Jurnal Kedokteran dan Kesehatan Indonesia |
| رقم الانضمام: | edsbas.930589C1 |
| قاعدة البيانات: | BASE |
| DOI: | 10.20885/JKKI.Vol11.Iss2.art11 |
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