دورية أكاديمية
IL-6 levels are associated with clinical status in patients with Myasthenia Gravis
| العنوان: | IL-6 levels are associated with clinical status in patients with Myasthenia Gravis |
|---|---|
| المؤلفون: | Braz, Nayara Felicidade Tomaz, Campos-Carl, Salvina Maria, Vieira, Érica Leandro Marciano, Rocha, Natalia Pessoa Rocha Pessoa, Gomez, Rodrigo Santiago, Kakehasi, Adriana Maria, Teixeira, Antonio Lúcio |
| المصدر: | Revista Brasileira de Neurologia; v. 57, n. 4 (2021) ; 2447-2573 ; 0101-8469 ; 10.46979/rbn.v57i4 |
| بيانات النشر: | Revista Brasileira de Neurologia |
| سنة النشر: | 2022 |
| المجموعة: | Portal de Periódicos da UFRJ (Universidade Federal do Rio de Janeiro) |
| مصطلحات موضوعية: | Neurologia, myasthenia gravis, immune system, cytokines, interleukin 6, MG composite |
| الوصف: | Background: Myasthenia gravis (MG) is an autoimmune disease marked by fluctuating course of muscle weakness. Objectives: The current study was designed to evaluate plasma levels of cytokines (IL-2, IL-4, IL-6, IL-10, TNF, IFN-γ, and IL17A) in patients with MG and controls and to investigate whether cytokines levels are associated with clinical parameters. This study was conducted at the Neuromuscular Diseases Outpatient Clinic, Hospital das Clínicas, Universidade Federal de Minas Gerais (UFMG), Brazil. Methods: Peripheral blood was drawn, and plasma levels of cytokines were measured by cytometric bead array (CBA) in 80 treated patients with MG and 50 controls. The MG Composite (MGC) was used to evaluate muscle weakness and severity of typical motor symptoms of MG. Results: Patients with MG undergoing treatment exhibit lower levels of all evaluated cytokines compared to controls. There was a negative correlation between IL-6 levels and the MG Composite score, indicating that higher levels of IL-6 were associated with better control of the disease. Conclusion: This exploratory study suggests that IL-6 is associated with MG clinical status, as assessed by the MGC |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | https://revistas.ufrj.br/index.php/rbn/article/view/50353/IL-6%20levels%20are%20associated%20with%20clinical%20status%20in%20patients%20with%20Myasthenia%20GravisTest; https://revistas.ufrj.br/index.php/rbn/article/view/50353Test |
| DOI: | 10.46979/rbn.v57i4.50353 |
| الإتاحة: | https://doi.org/10.46979/rbn.v57i4.50353Test https://doi.org/10.46979/rbn.v57i4Test https://revistas.ufrj.br/index.php/rbn/article/view/50353Test |
| حقوق: | Direitos autorais 2022 Revista Brasileira de Neurologia ; http://creativecommons.org/licenses/by/4.0Test |
| رقم الانضمام: | edsbas.C2409107 |
| قاعدة البيانات: | BASE |
| DOI: | 10.46979/rbn.v57i4.50353 |
|---|