التفاصيل البيبلوغرافية
| العنوان: |
Deep phenotyping of dementia in a multi-ethnic cardiovascular cohort: The Multi-Ethnic Study of Atherosclerosis (MESA) |
| المؤلفون: |
Ostovaneh, Mohammad R., Hughes, Timothy M., Wu, Colin O., McClelland, Robyn L., Casanova, Ramon, Bluemke, David A., Tracy, Russell P., Shea, Steven, Heckbert, Susan R., Lima, João A. C., Ambale-Venkatesh, Bharath |
| المساهمون: |
Nakamizo, Tomoki, NHLBI Division of Intramural Research, National Center for Research Resources |
| المصدر: |
PLOS ONE ; volume 19, issue 4, page e0298952 ; ISSN 1932-6203 |
| بيانات النشر: |
Public Library of Science (PLoS) |
| سنة النشر: |
2024 |
| المجموعة: |
PLOS Publications (via CrossRef) |
| الوصف: |
Background Our understanding of the specific aspects of vascular contributions to dementia remains unclear. Objectives We aim to identify the correlates of incident dementia in a multi-ethnic cardiovascular cohort. Methods A total of 6806 participants with follow-up data for incident dementia were included. Probable dementia diagnoses were identified using hospitalization discharge diagnoses according to the International Classification of Diseases Codes (ICD). We used Random Forest analyses to identify the correlates of incident dementia and cognitive function from among 198 variables collected at the baseline MESA exam entailing demographic risk factors, medical history, anthropometry, lab biomarkers, electrocardiograms, cardiovascular magnetic resonance imaging, carotid ultrasonography, coronary artery calcium and liver fat content. Death and stroke were considered competing events. Results Over 14 years of follow-up, 326 dementia events were identified. Beyond age, the top correlates of dementia included coronary artery calcification, high sensitivity troponin, common carotid artery intima to media thickness, NT-proBNP, physical activity, pulse pressure, tumor necrosis factor-α, history of cancer, and liver to spleen attenuation ratio from computed tomography. Correlates of cognitive function included income and physical activity, body size, serum glucose, glomerular filtration rate, measures of carotid artery stiffness, alcohol use, and inflammation indexed as IL-2 and TNF soluble receptors and plasmin-antiplasmin complex. Conclusion In a deeply phenotyped cardiovascular cohort we identified the key correlates of dementia beyond age as subclinical atherosclerosis and myocyte damage, vascular function, inflammation, physical activity, hepatic steatosis, and history of cancer. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
English |
| DOI: |
10.1371/journal.pone.0298952 |
| الإتاحة: |
https://doi.org/10.1371/journal.pone.0298952Test |
| حقوق: |
http://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: |
edsbas.5BDC5257 |
| قاعدة البيانات: |
BASE |
