دورية أكاديمية
The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease
| العنوان: | The Difference Quantity of Urinary Peptides between Two Groups of Type 2 Diabetic Patients with or without Coronary Artery Disease |
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| المؤلفون: | Fu, Guangzhen, Hu, Mei, Chu, Lina, Zhang, Man |
| المساهمون: | Zhang, M (reprint author), Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China., Peking Univ Ninth Sch Clin Med, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China., Capital Med Univ, Beijing Shijitan Hosp, Dept Clin Lab, Beijing 100038, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY |
| سنة النشر: | 2015 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | CARDIOVASCULAR-DISEASE, FIBRINOPEPTIDE-A, RISK-FACTORS, BIOMARKERS, DISCOVERY, FIBRINOGEN, PROTEOMICS, MELLITUS, CANCER, HEART |
| الوصف: | Objectives. We aim to explore urinary biomarkers that could monitor CAD in type 2 diabetic patients. Materials and Methods. Urine samples from two groups, twenty-eight type 2 diabetic patients with coexisting CAD and thirty type 2 diabetic patients without CAD, were purified by MB-WCX and then analyzed by MALDI-TOF-MS. Subsequently, we compared the urinary peptide signatures of the two groups by use of ClinProTools2.1 and evaluated the potential ability of the differently expressed peptides to distinguish type 2 diabetic patients with coexisting CAD from type 2 diabetic patients without CAD by ROC analysis. Finally, the differently expressed peptides were identified by nanoliquid chromatography-tandem mass spectrometry. Results. There were six differently expressed peptides (m/z 1305.2, 1743.9, 2184.9, 2756.1, 3223.2, and 6196.1) between the two groups of subjects, and they were identified as fragments of isoform 1 of fibrinogen alpha chain precursor, prothrombin precursor, and interalpha-trypsin inhibitor heavy chain H4. The diagnostic efficacy of m/z 2756.1 and m/z 3223.2 was better than the other peptides. Area under ROC of the m/z 2756.1, and m/z 3223.2 was 0.98 and 0.93, respectively. Conclusions. These urinary peptides are potential urinary biomarkers for monitoring of type 2 diabetic patients with CAD. ; Capital Health Research and Development of Special [2011-2008-02]; National Key Technology R&D Program: Key technology and application research of pre-pregnacy eugenics [2013BAI12B01-4] ; SCI(E) ; PubMed ; ARTICLE ; mzhang99@aliyun.com ; 758402 ; 2015 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1687-8337 1687-8345 |
| العلاقة: | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.2015.; 1302773; http://hdl.handle.net/20.500.11897/419235Test; WOS:000355463600001 |
| DOI: | 10.1155/2015/758402 |
| الإتاحة: | https://doi.org/20.500.11897/419235Test https://doi.org/10.1155/2015/758402Test https://hdl.handle.net/20.500.11897/419235Test |
| رقم الانضمام: | edsbas.F4DA55F3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 16878337 16878345 |
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| DOI: | 10.1155/2015/758402 |