دورية أكاديمية
Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics
| العنوان: | Studies on the drug-loading mechanism of polybutylcyanocrylate nanoparticle and its stability of thermodynamics |
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| المؤلفون: | Zhang Xue-Nong, Gong Jing-Hong, Tang Li-Hua, Zhang Qiang |
| المساهمون: | Zhang, XN (reprint author), Soochow Univ, Coll Pharm, DuShuHu High Educ Zone, Suzhou 215123, Jiang Su Prov, Peoples R China., Soochow Univ, Coll Pharm, Suzhou 215123, Jiang Su Prov, Peoples R China., Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China., Soochow Univ, Coll Pharm, DuShuHu High Educ Zone, Suzhou 215123, Jiang Su Prov, Peoples R China. |
| المصدر: | SCI ; EI |
| بيانات النشر: | current nanoscience |
| سنة النشر: | 2008 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | albendazole, nanoparticle, load-drug mechanism, stability, ECHINOCOCCOSIS, ADSORPTION, TISSUE |
| الوصف: | Aim of this paper is to study the load-drug mechanism of polybutylcyanocrylate nanoparticles and the physical stability of albendazole-polybutylcyanocrylate nanoparticle (ABZ-PBCA-NP). The adsorption mechanism between albendazole with polybutylcyanocrylate nanoparticle in different phosphate buffer solution (PBS) were investigated with isothermadsorption method. The constants of stability constants of albendazole-loading nanoparticles were predicted by determined the conductance rate of nanoparticles colloid under predetermined temperature in interval time. At the same time, several stabilizer including polyvinyl pyrrolidone (PVP), carboxymethylcellulose sodium (CMC-Na) and hydroxoy-propyl methyl cellulose (HPMC) was screen for improving stability and fluidity of nanoparticle suspension. The results showed that the mechanism of drug-load in nanoparticle was fitted the Langmuir equation. The conductance rate indicated that load-drug nanoparticle in suspension was unstability due to nature aggregation tendency and improved by reinforced with 4% PVP in solution. ; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000254019100006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701Test ; Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; SCI(E) ; EI ; 7 ; ARTICLE ; 1 ; 59-61 ; 4 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 1573-4137 |
| العلاقة: | CURRENT NANOSCIENCE.2008,4,(1),59-61.; 963339; http://hdl.handle.net/20.500.11897/397572Test; WOS:000254019100006 |
| DOI: | 10.2174/157341308783591834 |
| الإتاحة: | https://doi.org/20.500.11897/397572Test https://doi.org/10.2174/157341308783591834Test https://hdl.handle.net/20.500.11897/397572Test |
| رقم الانضمام: | edsbas.C6371F9B |
| قاعدة البيانات: | BASE |
| تدمد: | 15734137 |
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| DOI: | 10.2174/157341308783591834 |