Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese

التفاصيل البيبلوغرافية
العنوان:	Genome-wide association study identifies 8p21.3 associated with persistent hepatitis B virus infection among Chinese
المؤلفون:	Li, Yuanfeng, Si, Lanlan, Zhai, Yun, Hu, Yanling, Hu, Zhibin, Bei, Jin-Xin, Xie, Bobo, Ren, Qian, Cao, Pengbo, Yang, Fei, Song, Qingfeng, Bao, Zhiyu, Zhang, Haitao, Han, Yuqing, Wang, Zhifu, Chen, Xi, Xia, Xia, Yan, Hongbo, Wang, Rui, Zhang, Ying, Gao, Chengming, Meng, Jinfeng, Tu, Xinyi, Liang, Xinqiang, Cui, Ying, Liu, Ying, Wu, Xiaopan, Li, Zhuo, Wang, Huifen, Li, Zhaoxia, Hu, Bo, He, Minghui, Gao, Zhibo, Xu, Xiaobing, Ji, Hongzan, Yu, Chaohui, Sun, Yi, Xing, Baocai, Yang, Xiaobo, Zhang, Haiying, Tan, Aihua, Wu, Chunlei, Jia, Weihua, Li, Shengpin
المساهمون:	Zhang, HX, Zhou, GQ (reprint author), Beijing Proteome Res Ctr, Beijing Inst Radiat Med, State Key Lab Prote, Beijing 100850, Peoples R China., Zhou, GQ (reprint author), Natl Engn Res Ctr Prot Drugs, Beijing 100850, Peoples R China., Zhou, GQ (reprint author), Natl Ctr Prot Sci Beijing, Beijing 100850, Peoples R China., Mo, ZN (reprint author), Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China., Beijing Proteome Res Ctr, Beijing Inst Radiat Med, State Key Lab Prote, Beijing 100850, Peoples R China., Natl Engn Res Ctr Prot Drugs, Beijing 100850, Peoples R China., Natl Ctr Prot Sci Beijing, Beijing 100850, Peoples R China., Guangxi Med Univ, Ctr Genom & Personalized Med, Nanning 530021, Guangxi, Peoples R China., Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, MOE Key Lab Modern Toxicol, Nanjing 210029, Jiangsu, Peoples R China., State Key Lab Oncol Southern China, Guangzhou 510060, Guangdong, Peoples R China., Guangxi Med Univ, Affiliated Canc Hosp, Nanning 530021, Guangxi, Peoples R China., Chinese Acad Med Sci, Inst Basic Med Sci, Natl Lab Med Mol Biol, Beijing 100005, Peoples R China., Capital Univ Med Sci, Affiliated Youan Hosp, Dept Infect Dis, Beijing 100069, Peoples R China., Beijing 302 Hosp, Liver Failure Treatment & Res Ctr, Beijing 100039, Peoples R China., Sun Yat Sen Univ, Affiliated Hosp 3, Dept Clin Lab, Guangzhou 510630, Guangdong, Peoples R China., BGI Shenzhen, Shenzhen 518031, Peoples R China., Nanjing Univ, Sch Clin, Jinling Hosp, Dept Gastroenterol & Hepatol, Nanjing 210002, Jiangsu, Peoples R China., Zhejiang Univ, Coll Med, Affiliated Hosp 1, Dept Gastroenterol, Hangzhou 310006, Zhejiang, Peoples R China., Peking Univ, Canc Hosp & Inst, Dept Hepatobiliary Surg 1, Beijing 100142, Peoples R China.
المصدر:	PubMed ; SCI
بيانات النشر:	NATURE COMMUNICATIONS
سنة النشر:	2016
المجموعة:	Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
مصطلحات موضوعية:	RNA-POLYMERASE-II, HEPATOCELLULAR-CARCINOMA, HAN CHINESE, X PROTEIN, INTERFERON INDUCTION, SUSCEPTIBILITY LOCI, GENETIC-VARIANTS, INTEGRATOR, ACTIVATION, POLYMORPHISM
الوصف:	Hepatitis B virus (HBV) infection is a common infectious disease. Here we perform a genome-wide association study (GWAS) among Chinese populations to identify novel genetic loci involved in persistent HBV infection. GWAS scan is performed in 1,251 persistently HBV infected subjects (PIs, cases) and 1,057 spontaneously recovered subjects (SRs, controls), followed by replications in four independent populations totally consisting of 3,905 PIs and 3,356 SRs. We identify a novel locus at 8p21.3 (index rs7000921, odds ratio = 0.78, P = 3.2 x 10(-12)). Furthermore, we identify significant expression quantitative trait locus associations for INTS10 gene at 8p21.3. We demonstrate that INST10 suppresses HBV replication via IRF3 in liver cells. In clinical plasma samples, we confirm that INST10 levels are significantly decreased in PIs compared with SRs, and negatively correlated with the HBV load. These findings highlight a novel antiviral gene INTS10 at 8p21.3 in the clearance of HBV infection. ; National Natural Science Foundation of China [81125017, 81222027]; Chinese National Programs for Fundamental Research and Development [2013CB910301]; Program of Beijing Municipal Commission for Science and Technology for Frontier Technology of Life Science [Z141100000214014]; Chinese National Programs for High Technology Research and Development [2012AA02A205, 2012AA020204, 2012AA022002]; Chinese Key Project for Infectious Diseases [2013ZX10002009]; International ST Cooperation [2014DFB30020] ; SCI(E) ; PubMed ; ARTICLE ; zengnanmo@hotmail.com; zhanghx08@126.com; zhougq114@126.com ; 11664 ; 7
نوع الوثيقة:	journal/newspaper
اللغة:	Chinese
تدمد:	2041-1723 27244555
العلاقة:	NATURE COMMUNICATIONS.2016,7.; 1389370; http://hdl.handle.net/20.500.11897/433532Test; WOS:000376823100001
DOI:	10.1038/ncomms11664
الإتاحة:	https://doi.org/20.500.11897/433532Test https://doi.org/10.1038/ncomms11664Test https://hdl.handle.net/20.500.11897/433532Test
رقم الانضمام:	edsbas.7A8C65D1
قاعدة البيانات:	BASE

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الوصف
تدمد:	20411723 27244555
DOI:	10.1038/ncomms11664