دورية أكاديمية
Novel loci and pathways significantly associated with longevity
| العنوان: | Novel loci and pathways significantly associated with longevity |
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| المؤلفون: | Zeng, Yi, Nie, Chao, Min, Junxia, Liu, Xiaomin, Li, Mengmeng, Chen, Huashuai, Xu, Hanshi, Wang, Mingbang, Ni, Ting, Li, Yang, Yan, Han, Zhang, Jin-Pei, Song, Chun, Chi, Li-Qing, Wang, Han-Ming, Dong, Jie, Zheng, Gu-Yan, Lin, Li, Qian, Feng, Qi, Yanwei, Liu, Xiao, Cao, Hongzhi, Wang, Yinghao, Zhang, Lijuan, Li, Zhaochun, Zhou, Yufeng, Wang, Yan, Lu, Jiehua, Li, Jianxin, Qi, Ming, Bolund, Lars, Yashin, Anatoliy, Land, Kenneth C., Gregory, Simon, Yang, Ze, Gottschalk, William, Tao, Wei, Wang, Jian, Wang, Jun, Xu, Xun, Bae, Harold, Nygaard, Marianne, C |
| المساهمون: | Zeng, Y (reprint author), Duke Univ, Ctr Study Aging & Human Dev, Durham, NC USA., Zeng, Y (reprint author), Duke Univ, Sch Med, Div Geriatr, Durham, NC USA., Zeng, Y (reprint author), Peking Univ, Ctr Healthy Aging & Dev Studies, Natl Sch Dev, Beijing 100871, Peoples R China., Yang, HM (reprint author), BGI Shenzhen, Shenzhen, Peoples R China., Tian, XL (reprint author), Peking Univ, Dept Human Populat Genet, Inst Mol Med, Beijing 100871, Peoples R China., Yang, HM (reprint author), James D Watson Inst Gen, Duke Univ, Ctr Study Aging & Human Dev, Durham, NC USA., Duke Univ, Sch Med, Div Geriatr, Durham, NC USA., Peking Univ, Ctr Healthy Aging & Dev Studies, Natl Sch Dev, Beijing 100871, Peoples R China., BGI Shenzhen, Shenzhen, Peoples R China., Zhejiang Univ, Sch Med, Affiliated Hosp 1, Inst Translat Med, Hangzhou 310003, Zhejiang, Peoples R China., Second Mil Med Univ, Dept Rheumatol & Immunol, Shanghai Changzheng Hosp, Shanghai, Peoples R China., Xiangtan Univ, Business Sch, Xiangtan, Peoples R China., Fudan Univ, State Key Lab Genet Engn, Shanghai 200433, Peoples R China., Fudan Univ, MOE Key Lab Contemporary Anthropol, Sch Life Sci, Shanghai 200433, Peoples R China., Peking Univ, Dept Human Populat Genet, Inst Mol Med, Beijing 100871, Peoples R China., Anhui Med Univ, Dept Biomed Engn, Sch Life Sci, Hefei, Peoples R China., Peking Univ, Dept Sociol, Beijing 100871, Peoples R China., Aarhus Univ, Dept Biomed, Aarhus, Denmark., Duke Univ, Populat Res Inst, Durham, NC USA., Duke Univ, Med Ctr, Duke Mol Physiol Inst, Durham, NC USA., Beijing Hosp, Natl Inst Geriatr, Minist Hlth, Beijing, Peoples R China., Duke Univ, Med Ctr, Dept Neurol, Durham, NC USA., Peking Univ, Sch Life Sci, Beijing 100871, Peoples R China., James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China., Univ Copenhagen, Dept Biol, Copenhagen, Denmark., Oregon State Univ, Coll Publ Hlth & Human Sci, Corvallis, OR 97331 USA., Univ Southern Denmark, Danish Aging Res Ctr, Unit Epidemiol Biostat & Biodemog, Inst Publ Hlth, Odense, Denmark., Univ Bologna, Dept Expt Diagnost & Specialty Med, Bologna, Italy., Univ Bologna, Interdept Ctr L Galvani, Bologna, Italy., Boston Univ, Sch Med, Geriatr Sect, Dept Med, Boston, MA 02118 USA., Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA., Leiden Univ, Med Ctr, Dept Mol Epidemiol & Netherlands Consortium Healt, Leiden, Netherlands., Max Planck Inst Demog Res, Rostock, Germany., Yang, HM (reprint author), James D Watson Inst Genome Sci, Hangzhou, Zhejiang, Peoples R China. |
| المصدر: | PubMed ; SCI |
| بيانات النشر: | SCIENTIFIC REPORTS |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | GENOME-WIDE ASSOCIATION, ALZHEIMERS-DISEASE, LIFE-SPAN, GENETIC ASSOCIATION, FOXO GENOTYPES, ADVANCED AGES, HAN CHINESE, METAANALYSIS, SURVIVAL, POPULATION |
| الوصف: | Only two genome-wide significant loci associated with longevity have been identified so far, probably because of insufficient sample sizes of centenarians, whose genomes may harbor genetic variants associated with health and longevity. Here we report a genome-wide association study (GWAS) of Han Chinese with a sample size 2.7 times the largest previously published GWAS on centenarians. We identified 11 independent loci associated with longevity replicated in Southern-Northern regions of China, including two novel loci (rs2069837-IL6; rs2440012-ANKRD20A9P) with genomewide significance and the rest with suggestive significance (P < 3.65 x 10(-5)). Eight independent SNPs overlapped across Han Chinese, European and U.S. populations, and APOE and 5q33.3 were replicated as longevity loci. Integrated analysis indicates four pathways (starch, sucrose and xenobiotic ; National Key Basic Research Program of China [2013CB530700]; National Natural Science Foundation of China [71233001, 71490732]; NIA/NIH [R01 AG023627, U19AG023122]; NIA/NIH (Pepper Center Grant) [P30AG028716]; European Union's Seventh Framework Programme (FP7) [259679] ; SCI(E) ; PubMed ; ARTICLE ; zengyi@duke.edu; tianxiaoli@pku.edu.cn; yanghm@genomics.org.cn ; 21243 ; 6 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 2045-2322 |
| العلاقة: | SCIENTIFIC REPORTS.2016,6.; 1390645; http://hdl.handle.net/20.500.11897/434762Test; WOS:000370792700001 |
| DOI: | 10.1038/srep21243 |
| الإتاحة: | https://doi.org/20.500.11897/434762Test https://doi.org/10.1038/srep21243Test https://hdl.handle.net/20.500.11897/434762Test |
| رقم الانضمام: | edsbas.99A87D43 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20452322 |
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| DOI: | 10.1038/srep21243 |