دورية أكاديمية
أعرض في EDS

Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease

التفاصيل البيبلوغرافية
العنوان: Predictors of high on-aspirin platelet reactivity in elderly patients with coronary artery disease
المؤلفون: Zhang, J. W., Liu, W. W., McCaffrey, Timothy A., He, X. Q., Liang, W. Y., Chen, X. H., Feng, X. R., Fu, Sidney W., Liu, M. L.
المساهمون: Liu, ML (reprint author), Peking Univ First Hosp, Dept Geriatr, 8 Xishiku St, Beijing 100034, Peoples R China., Peking Univ First Hosp, Dept Geriatr, 8 Xishiku St, Beijing 100034, Peoples R China., George Washington Univ, Med Ctr, Dept Med, Washington, DC USA.
المصدر: SCI
بيانات النشر: CLINICAL INTERVENTIONS IN AGING
سنة النشر: 2017
المجموعة: Peking University Institutional Repository (PKU IR) / 北京大学机构知识库
مصطلحات موضوعية: aspirin, platelet reactivity, elderly, risk factors, coronary artery disease, DUAL ANTIPLATELET THERAPY, LIGHT TRANSMISSION AGGREGOMETRY, URIC-ACID, METABOLIC SYNDROME, RENAL-FUNCTION, FUNCTION TESTS, BLEEDING RISK, CLOPIDOGREL, RESISTANCE, INTERVENTION
الوصف: Objectives: Previous studies have illustrated the link between high on-aspirin platelet reactivity (HAPR) with increasing thrombotic risks. The aim of our study was to investigate relative risk factors of HAPR in elderly patients with coronary artery disease. Methods: Elderly, hospitalized coronary artery disease patients on regular aspirin treatment were enrolled from January 2014 to September 2016. Medical records of each patient were collected, including demographic information, cardiovascular risk factors, concomitant drugs and routine biological parameters. Arachidonic acid (AA, 0.5 mg/mL) and adenosine diphosphate (ADP, 5 mu mol/L) induced platelet aggregation were measured via light transmission assay (LTA) to evaluate antiplatelet responses, referred as LTA-AA and LTA-ADP. Results: A total of 275 elderly patients were included, with mean age of 77.2 +/- 8.1 years, and males accounted for 81.8%. HAPR was defined as LTA-AA in the upper quartile of the enrolled population. HAPR patients tended to have lower renal function (P=0.052). Higher serum uric acid (SUA) level, as well as lower platelet count, hemoglobin and hematocrit were observed in HAPR patients, with a higher proportion of diuretics use (P<0.05). Multivariate analysis revealed that SUA (OR: 1.004, 95% CI: 1.000-1.007, P=0.048), platelet count (OR: 0.994, 95% CI: 0.989-1.000, P=0.045), hematocrit (OR: 0.921, 95% CI: 0.864-0.981, P=0.011) and concomitant P2Y12 receptor inhibitors use (OR: 1.965, 95% CI: 1.075-3.592, P=0.028) were correlated with HAPR. Spearman's correlation analysis demonstrated an inverse association of LTA-AA with hematocrit (r=-0.234, P<0.001), hemoglobin (r=-0.209, P<0.001) and estimated glomerular filtration rate (r=-0.132, P=0.031). Conclusion: SUA, platelet count, hematocrit and P2Y12 receptor inhibitors use were independently correlated with HAPR. These parameters might provide novel therapeutic targets for optimizing antiplatelet therapy. ; International Science & Technology Corporation Project of China ...
نوع الوثيقة: journal/newspaper
اللغة: English
تدمد: 1178-1998
العلاقة: CLINICAL INTERVENTIONS IN AGING.2017,12,1271-1279.; 1910464; http://hdl.handle.net/20.500.11897/475873Test; WOS:000407311300002
DOI: 10.2147/CIA.S138592
الإتاحة: https://doi.org/20.500.11897/475873Test
https://doi.org/10.2147/CIA.S138592Test
https://hdl.handle.net/20.500.11897/475873Test
رقم الانضمام: edsbas.B1D4FA0C
قاعدة البيانات: BASE
الوصف
تدمد:11781998
DOI:10.2147/CIA.S138592