دورية أكاديمية
Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme
| العنوان: | Relationship between magnetic resonance imaging and molecular pathology in patients with glioblastoma multiforme |
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| المؤلفون: | Li Wen-bin, Tang Kai, Zhang Wei, Yan Wei, You Gang, Li Shao-wu, Zhang Long, Huang Yan-jie, Jiang Tao |
| المساهمون: | Jiang, T (reprint author), Capital Med Univ, Dept Neurosurg, Beijing 100050, Peoples R China., Capital Med Univ, Beijing Tiantan Hosp, Dept Neurosurg, Beijing 100050, Peoples R China., Capital Med Univ, Beijing Tiantan Hosp, Dept Radiol, Beijing 100050, Peoples R China., Capital Med Univ, Beijing Shijitan Hosp, Ctr Canc, Beijing 100038, Peoples R China., Peking Univ, Coll Publ Hlth, Beijing 100083, Peoples R China., Capital Med Univ, Dept Neurosurg, Beijing 100050, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | Chinese Medical Journal |
| سنة النشر: | 2011 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | glioblastoma multiforme, magnetic resonance imaging, molecular pathology, GENE-EXPRESSION, ANGIOGENESIS, INVASION, SUBTYPES, GLIOMA, TUMORS |
| الوصف: | Background Glioblastoma multiforme (GBM) is the most common and lethal primary brain tumor in adults. Magnetic resonance imaging (MRI) is routinely used in the diagnosis, characterization and clinical management of GBM. The diagnosis and treatment of GBM is largely guided by histopathology and immunohistochemistry. This study aimed to identify the relationship between magnetic resonance features and molecular pathology of GBM. Methods MRI images of 43 glioblastoma patients were collected. Four imaging features, degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor across the midline, were selected to identify their relationship with P53, Ki-67 and O(6)-methylguanine-DNA methltransferase (MGMT) expression in patients with GBM. The relationship between imaging features and molecular pathology was studied by chi-square test using the software SPSS 13.0. Results High expression of P53 was found correlated with low contrast tumor enhanced/T2 ratio, low expression of Ki-67 was correlated with multiple lesions and high expression of KI-67 may be related with tumor across the midline, low expression of MGMT was correlated with edema. Conclusion Some MRI features such as the degree of edema, contrast tumor enhanced/T2 ratio, multiple lesions and tumor acrossing the midline are correlated with P53, Ki-67 and MGMT of GBM. Chin Med J 2011;124(17):2589-2592 ; Medicine, General & Internal ; SCI(E) ; 中国科技核心期刊(ISTIC) ; 中国科学引文数据库(CSCD) ; 1 ; ARTICLE ; 17 ; 2589-2592 ; 124 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0366-6999 |
| العلاقة: | CHINESE MEDICAL JOURNAL.2011,124,(17),2589-2592.; 899480; http://hdl.handle.net/20.500.11897/394364Test; WOS:000295297400005 |
| DOI: | 10.3760/cma.j.issn.0366-6999.2011.17.005 |
| الإتاحة: | https://doi.org/20.500.11897/394364Test https://doi.org/10.3760/cma.j.issn.0366-6999.2011.17.005Test https://hdl.handle.net/20.500.11897/394364Test |
| رقم الانضمام: | edsbas.207758B3 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 03666999 |
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| DOI: | 10.3760/cma.j.issn.0366-6999.2011.17.005 |