دورية أكاديمية
Baofukang suppository promotes the repair of vaginal epithelial cells in response to Candida albicans
| العنوان: | Baofukang suppository promotes the repair of vaginal epithelial cells in response to Candida albicans |
|---|---|
| المؤلفون: | Li, Ting, Niu, Xiaoxi, Zhang, Xu, Wang, Suxia, Liu, Zhaohui |
| المساهمون: | Liu, ZH (reprint author), Peking Univ, Hosp 1, Dept Obstet & Gynecol, 8 Xishiku St, Beijing 100034, Peoples R China., Peking Univ, Hosp 1, Dept Obstet & Gynecol, 8 Xishiku St, Beijing 100034, Peoples R China., Peking Univ, Hosp 1, Lab Electron Microscopy, Ultrastruct Pathol Ctr, Beijing 100034, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | AMB Express |
| سنة النشر: | 2016 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Vulvovaginal candidiasis, Vaginal epithelial cells, Candida albicans, Baofukang suppository, Cytokines, HOST-DEFENSE, IN-VITRO, ORAL CANDIDIASIS, IMMUNOGLOBULIN-G, IMMUNITY, DESFLURANE, PROPOFOL, INNATE, CANCER, IL-17 |
| الوصف: | Vulvovaginal candidiasis (VVC) is an opportunistic fungal infection predominantly caused by Candida albicans affecting a significant number of women of reproductive age. The Chinese medicine, the Baofukang suppository is widely used in the clinic for its antimicrobial activity and is therefore of great interest as a potential antifungal drug for the prevention of VVC. We evaluated the cytotoxic activity of the Baofukang suppository using the VK2/E6E7 vaginal epithelial cell (VEC) line. When treated with the Baofukang suppository, all of the immunocompetent cytokines and chemokines (e.g., IL-2, IL-4, IL-6, IL-8, and IL-17) by infected VK2/E6E7 cells was statistically up-regulated (P < 0.05), except IL-4 (11.70 +/- 1.82 vs. 14.88 +/- 4.72, P = 0.343) compared to the infected control cells. The secretion of non-B IgG also exhibited the same trend. Our scanning electron microscopy results revealed that C. albicans can invade VECs by both induced endocytosis and active penetration. The Baofukang suppository could effectively inhibit the adhesion, hyphal formation, and proliferation, as well as notably restore the vaginal epithelial cell morphology, viability, and enhance the local immune function of the VECs. These preliminary results suggest promising antimicrobial properties of the Baofukang suppository, which may be efficacious as an antifungal therapy candidate via up-regulating Th1 cellular immunity, the Th17-axis of the innate immune response, and the secretion of vaginal epithelial-derived IgG. These combined effects collectively restore the immune function of the infected VECs against C. albicans in vitro. ; National Natural Science Foundation of China [81571394] ; SCI(E) ; ARTICLE ; 17301255426@163.com ; 6 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 2191-0855 |
| العلاقة: | AMB Express.2016,6.; 1516646; http://hdl.handle.net/20.500.11897/458465Test; WOS:000389470800001 |
| DOI: | 10.1186/s13568-016-0281-1 |
| الإتاحة: | https://doi.org/20.500.11897/458465Test https://doi.org/10.1186/s13568-016-0281-1Test https://hdl.handle.net/20.500.11897/458465Test |
| رقم الانضمام: | edsbas.C01C1CA1 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 21910855 |
|---|---|
| DOI: | 10.1186/s13568-016-0281-1 |