دورية أكاديمية
The effects of morphine on basal neuronal activities in the lateral and medial pain pathways
| العنوان: | The effects of morphine on basal neuronal activities in the lateral and medial pain pathways |
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| المؤلفون: | Su, Yuan-Lin, Huang, Jin, Wang, Ning, Wang, Jin-Yan, Luo, Fei |
| المساهمون: | Wang, JY (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China., Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China., Chinese Acad Sci, Grad Univ, Beijing 100101, Peoples R China., Peking Univ, Hlth Sci Ctr, Dept Neurobiol, Beijing 100871, Peoples R China., Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, 4A Datun Rd, Beijing 100101, Peoples R China. |
| المصدر: | SCI |
| بيانات النشر: | 神经科学快报 |
| سنة النشر: | 2012 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Morphine, Spontaneous activity, The primary somatosensory cortex, The anterior cingulate cortex, Thalamus, ANTERIOR CINGULATE CORTEX, THALAMIC NUCLEI, RATS, STIMULATION, RESPONSES, BRAIN, DIZOCILPINE, ACTIVATION, EXCITATION, ANALGESIA |
| الوصف: | Numerous studies indicate that morphine suppresses pain-evoked activities in both spinal and supraspinal regions. However, little is known about the effect of morphine on the basal brain activity in the absence of pain. The present study was designed to assess the effects of single-dose morphine on the spontaneous discharge of many simultaneously recorded single units, as well as their functional connections, in the lateral pain pathway, including the primary somatosensory cortex (SI) and ventral posterolateral thalamus (VPL), and medial pain pathway, including the anterior cingulate cortex (ACC) and medial dorsal thalamus (MD), in awake rats. Morphine (5 mg/kg) was administered intraperitoneally before the recording. Naloxone plus morphine and normal saline injections were performed respectively as controls. The results showed that morphine administration produced significant changes in the spontaneous neuronal activity in more than one third of the total recorded neurons, with primary activation in the lateral pathway while both inhibition and activation in the medial pathway. Naloxone pretreatment completely blocked the effects induced by morphine. In addition, the correlated activities between and within both pain pathways was exclusively suppressed after morphine injection. These results suggest that morphine may play different roles in modulating neural activity in normal vs. pain states. Taken together, this is the first study investigating the morphine modulation of spontaneous neuronal activity within parallel pain pathways. It can be helpful for revealing neuronal population coding for the morphine action in the absence of pain, and shed light on the supraspinal mechanisms for preemptive analgesia. (C) 2012 Elsevier Ireland Ltd. All rights reserved. ; Neurosciences ; SCI(E) ; 4 ; ARTICLE ; 2 ; 173-178 ; 525 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0304-3940 |
| العلاقة: | NEUROSCIENCE LETTERS.2012,525,(2),173-178.; 865157; http://hdl.handle.net/20.500.11897/230811Test; WOS:000309015600017 |
| DOI: | 10.1016/j.neulet.2012.07.032 |
| الإتاحة: | https://doi.org/20.500.11897/230811Test https://doi.org/10.1016/j.neulet.2012.07.032Test https://hdl.handle.net/20.500.11897/230811Test |
| رقم الانضمام: | edsbas.1D878949 |
| قاعدة البيانات: | BASE |
| تدمد: | 03043940 |
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| DOI: | 10.1016/j.neulet.2012.07.032 |