دورية أكاديمية
Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: Results of the DYSlipidemia International Study (DYSIS)
| العنوان: | Prevalence of dyslipidaemia in patients treated with lipid-lowering agents in China: Results of the DYSlipidemia International Study (DYSIS) |
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| المؤلفون: | Zhao, Shuiping, Wang, Yongjun, Mu, Yiming, Yu, Bilian, Ye, Ping, Yan, Xiaowei, Li, Zhanquan, Wei, Yidong, Ambegaonakr, Baishaili M., Hu, Dayi |
| المساهمون: | Hu, DY (reprint author), Peking Univ, Peoples Hosp, Dept Cardiol, 11 Xi Zhi Men Nan Da Jie, Beijing 100044, Peoples R China., Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Changsha 410011, Hunan, Peoples R China., Capital Med Univ, Beijing Tiantan Hosp, Dept Neurol, Beijing 100050, Peoples R China., Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing 100853, Peoples R China., Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Cardiol, Beijing 100853, Peoples R China., Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Cardiol, Beijing 100730, Peoples R China., Peking Union Med Coll, Beijing 100730, Peoples R China., Peoples Hosp Liaoning Prov, Dept Cardiol, Shenyang 110016, Peoples R China., Tonidi Univ, Peoples Hosp 10, Dept Cardiol, Shanghai 200072, Peoples R China., Merck & Co Inc, Whitehouse Stn, NJ USA., Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China., Peking Univ, Peoples Hosp, Dept Cardiol, 11 Xi Zhi Men Nan Da Jie, Beijing 100044, Peoples R China. |
| المصدر: | PubMed ; EI ; SCI |
| بيانات النشر: | atherosclerosis |
| سنة النشر: | 2014 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | Cardiovascular diseases, Dyslipidaemia, Statin, Lipid-lowering agents, LDL cholesterol, Non-HDL cholesterol, CORONARY-HEART-DISEASE, HIGH-DENSITY LIPOPROTEIN, CLINICAL-PRACTICE, CHOLESTEROL GOAL, DIABETES-MELLITUS, HIGH-RISK, MANAGEMENT, ABNORMALITIES, CANADA |
| الوصف: | Background: Despite clear guideline recommendations, there is a paucity of data regarding the prevalence and type of persistent lipid profile abnormalities in patients on stable lipid-lowering therapy in China. Methods: This cross-sectional trial included 25,697 patients treated with lipid-lowering agents from 122 centres between April 2012 and October 2012; all underwent clinical examination and had their latest fasting lipid profiles while on lipid-lowering therapy recorded. Logistic regression was performed to assess predictors for lipid abnormalities classified according to current Chinese guidelines. Findings: Overall, 29.1% of patients had no lipid abnormalities, and 38.5% of patients did not achieve the therapeutic goal for low-density lipoprotein cholesterol (LDL-C), either as a single lipid anomaly or associated with low high-density lipoprotein cholesterol (HDL-C), elevated triglycerides, or both. Subjects with low risk were more likely than those with very high and high risk to be at target LDL-C levels. Furthermore, 10.4% of very high-risk patients and 11.1% of high-risk patients who attained the LDL-C goal failed to attain non-HDL-C goals. Diabetes was shown to be a strong predictor of failure in attaining non-HDL-C and both goals (OR 3.03; 3.22, 95% CI 2.58-3.55; 2.73-3.79, respectively). Conclusion: Although great improvements have been made over the past decade, the large majority of very high-risk and high-risk patients treated with lipid-lowing agents still had one or more manifestations of dyslipidaemia. Further clinical evidence is needed to clarify whether adding other lipid-lowering agents to a statin will be associated with additional cardiovascular risk reduction. (C) 2014 Elsevier Ireland Ltd. All rights reserved. ; Peripheral Vascular Disease ; SCI(E) ; EI ; PubMed ; 6 ; ARTICLE ; dayi.hu@medmail.com.cn ; 2 ; 463-469 ; 235 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0021-9150 1879-1484 |
| العلاقة: | ATHEROSCLEROSIS.2014,235,(2),463-469.; 652202; http://hdl.handle.net/20.500.11897/188936Test; WOS:000342411000932 |
| DOI: | 10.1016/j.atherosclerosis.2014.05.916 |
| الإتاحة: | https://doi.org/20.500.11897/188936Test https://doi.org/10.1016/j.atherosclerosis.2014.05.916Test https://hdl.handle.net/20.500.11897/188936Test |
| رقم الانضمام: | edsbas.84E77F0F |
| قاعدة البيانات: | BASE |
| تدمد: | 00219150 18791484 |
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| DOI: | 10.1016/j.atherosclerosis.2014.05.916 |