دورية أكاديمية
The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells
| العنوان: | The crosstalk between p38 and Akt signaling pathways orchestrates EMT by regulating SATB2 expression in NSCLC cells |
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| المؤلفون: | Küçüksayan, Hakan, Akça, Hakan |
| بيانات النشر: | SAGE Publications Ltd |
| سنة النشر: | 2017 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | epithelial–mesenchymal transition, Akt, non-small-cell lung cancer, p38, SATB2, mitogen activated protein kinase p38, phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase, protein kinase B, transcription factor, transcription factor SATB2, unclassified drug, matrix attachment region binding protein, PTEN protein, human, SATB2 protein, Akt signaling, Article, AT rich sequence, controlled study, enzyme activation, epigenetics, epithelial mesenchymal transition, gene silencing, lung metastasis, lung non-small cell carcinoma cell line, molecular dynamics, molecular interaction, non small cell lung cancer, priority journal, protein expression |
| الوصف: | Epithelial–mesenchymal transition is a crucial event for metastasis and could be mediated by several pathways such as phosphoinositide 3-kinase/Akt, mitogen-activated protein kinases, as well as many epigenetic regulators. Special AT-rich sequence-binding protein 2 is an epigenetic regulator involved in epithelial–mesenchymal transition and osteoblastic differentiation. It has been reported that the crosstalk between several pathways is responsible for the regulation of epithelial–mesenchymal transition in cancer cells. However, crosstalks between p38 and Akt pathways involved in epithelial–mesenchymal transition are still unknown. We recently reported that there is a crosstalk between p38 and Akt pathways in non-small-cell lung carcinoma cells, and this crosstalk is associated with E-cadherin and special AT-rich sequence-binding protein 2 expressions. Therefore, we aimed to determine whether this crosstalk has a mediator role in the regulation of epithelial–mesenchymal transition in non-small-cell lung carcinoma. Our results showed that inhibition of p38 leads to the disruption of this crosstalk via decreased expression of phosphatase and tensin homolog (PTEN) and subsequently increased activation of Akt in non-small-cell lung carcinoma cells. Then, we found that p38 inhibition upregulated special AT-rich sequence-binding protein 2 expression and reversed epithelial–mesenchymal transition in non-small-cell lung carcinoma cells. Furthermore, special AT-rich sequence-binding protein 2 knockdown abolished the effect of p38 inhibition on epithelial–mesenchymal transition in non-small-cell lung carcinoma cells. In conclusion, our results strongly indicate that the crosstalk between p38 and Akt pathways can determine special AT-rich sequence-binding protein 2 expression and epithelial character of non-small-cell lung carcinoma cells, and special AT-rich sequence-binding protein 2 is a critical epigenetic regulator for epithelial–mesenchymal transition mediated by p38 pathway in non-small-cell lung ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-383616-5 0-00-383616-9 |
| تدمد: | 1010-4283 |
| العلاقة: | Tumor Biology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/8928Test; https://doi.org/10.1177/1010428317706212Test; 39; 2-s2.0-85031408155; WOS:000383616901419 |
| DOI: | 10.1177/1010428317706212 |
| الإتاحة: | https://doi.org/10.1177/1010428317706212Test https://hdl.handle.net/11499/8928Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.25014166 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780003836165 0003836169 |
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| تدمد: | 10104283 |
| DOI: | 10.1177/1010428317706212 |