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1دورية أكاديمية
المؤلفون: Tüzün, T., Ekinci, Y.
مصطلحات موضوعية: meropenem, methylprednisolone, piperacillin plus tazobactam, troponin, adult, aged, Article, case report, clinical article, colon cancer, computer assisted tomography, coronary artery disease, coronavirus disease 2019, erythrocyte sedimentation rate, heart infarction, human, hypertension, male, middle aged, pneumomediastinum, COVID-19, spontaneous pneumothorax, C reactive protein, ceftriaxone, D dimer, dexamethasone, ferritin, lactate dehydrogenase, levofloxacin, subdural hematoma
الوصف: Introduction: We aimed to describe the clinical characteristics and outcomes of patients with spontaneous pneumothorax (SPT) and pneumomediastinum (SPM) due to COVID-19 pneumonia. Methodology: This retrospective study evaluated inpatients at a COVID-19 pandemic hospital. Between March 11, 2020 and March 31, 2021, patients who developed complications of spontaneous pneumothorax (SPT) and pneumomediastinum (SPM) with a confirmed diagnosis of SARS-CoV-2 by polymerase chain reaction (PCR) method were included. Results: Of the 6,528 hospitalized patients, nine developed complications of SPT and SPM, with an incidence of 0.14%. Four of these patients developed SPT, one developed SPM, one developed SPT + SPM + emphysema, and three developed SPT + SPM. The mean age of the patients was 67.67 ± 13.41 years and the median was 68 (45-88) years. All patients were male. Six patients died, one of whom died of myocardial infarction from uncomplicated causes. Conclusions: Studies with more cases are needed to evaluate the causality between COVID-19 and pneumothorax (PT) and pneumomediastinum (PM). However, it should be kept in mind that PT and PM may lead to this clinic when sudden respiratory distress occurs in these patients and rapid diagnosis and treatment should be planned. As observed in this study, PT and PM are important factors in the development of mortality in COVID-19 patients. Copyright © 2023 Tüzün et al.
العلاقة: Journal of Infection in Developing Countries; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.3855/jidc.18048Test; https://hdl.handle.net/11499/56735Test; 17; 12; 1682; 1689; 2-s2.0-85183269675; WOS:001165532000001
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2دورية أكاديمية
المؤلفون: Paydas, Semra, Çeneli, Özcan, Karakus, Sema, Ipek, Yildiz, Kis, Cem, Maral, Senem, Ekinci, Omer, Guven, Zeynep Tugba, Gündüz E., Ãœmit E.G., Cagliyan, Gulsum Akgun, Akdeniz, Aydan, Celkan, Tiraje, Sengoz, Ceyda Ozcelik, Karatas, Ayse, Bulduk, Tuba, Ozcan, Alper, Apak, Fatma Burcu Belen, Canbolat, Aylin, Kartal, Ibrahim, Oren, Hale, Toret, Ersin, Ozdemir, Gul Nihal, Ozturk, Sule Mine Bakanay, Kırkızlar H.O., Gülsaran S.K., Özkocaman V., ÖzkalemkaÅŸ F., Candar Ö., Elverdi, Tugrul, Kucukyurt, Selin
مصطلحات موضوعية: doxorubicin, etoposide, hyalin, immunoglobulin A, immunoglobulin G, Castleman disease, Multicentric, Treatment, Unicentric, acute phase protein, bendamustine, C reactive protein, CD3 antigen, cyclophosphamide, cyclophosphamide plus doxorubicin plus prednisolone plus rituximab plus vincristine, cyclosporine, interleukin 6, lactate dehydrogenase, lenalidomide, methylprednisolone, olanzapine, prednisolone, prednisone, rituximab, siltuximab, tocilizumab, vincristine, abdominal pain, adult, anemia
الوصف: Objective: Castleman disease (CD) is a rare disease also known as angiofollicular lymph node hyperplasia. The two main histological subtypes are the hyaline vascular and plasma cell variants. It is further classified as unicentric CD (UCD) or multicentric CD (MCD) according to the anatomical distribution of the disease and the number of lymph nodes involved. The aim of this multicenter study was to evaluate all cases of CD identified to date in Turkey to set up a national registry to improve the early recognition, treatment, and follow-up of CD. Materials and Methods: Both adult (n=130) and pediatric (n=10) patients with lymph node or involved field biopsy results reported as CD were included in the study. Patients’ demographic information, clinical and laboratory characteristics, imaging study results, treatment strategies, and clinical outcomes were evaluated retrospectively. Results: A total of 140 patients (69 male and 71 female) with a diagnosis of UCD (n=73) or MCD (n=67) were included. The mean age was 39 years in the UCD group and 47 years in the MCD group. Female patients were more common in the UCD group. The most common histological subtype was hyaline vascular for both UCD and MCD patients. Asymptomatic patients were more common in the UCD group. Anemia, elevations of acute phase reactants, and hypoalbuminemia were more common in the MCD group. The most commonly used treatment strategies for UCD were surgical excision, rituximab, and radiotherapy, respectively. All UCD patients were alive at a median of 19.5 months of follow-up. The most commonly used treatment strategies for MCD were methyl prednisolone, R-CHOP, R-CVP, and rituximab. Thirteen MCD patients had died at a median of 34 months of follow-up. Conclusion: This study is important in presenting the patient characteristics and treatment strategies for CD from Turkey, with the potential of increasing awareness about CD. Treatment data may help in making decisions, particularly in countries that do not have access to siltuximab. However, ...
العلاقة: Turkish Journal of Hematology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.4274/tjh.galenos.2022.2021.0670Test; https://search.trdizin.gov.tr/yayin/detay/515131Test; https://hdl.handle.net/11499/47815Test; 39; 130; 135; 2-s2.0-85131226359; WOS:000810203000006
الإتاحة: https://doi.org/10.4274/tjh.galenos.2022.2021.0670Test
https://hdl.handle.net/11499/47815Test
https://search.trdizin.gov.tr/yayin/detay/515131Test -
3
المؤلفون: BüyükaÅŸik, Y., Alayvaz, Aslan, N., Sayinalp, N.
مصطلحات موضوعية: ADP ribosyl cyclase/cyclic ADP ribose hydrolase 1, beta 2 microglobulin, lactate dehydrogenase, adult, aged, bone marrow, cancer patient, cancer prognosis, cancer staging, cancer survival, chronic lymphatic leukemia, Conference Paper, controlled study, female, fluorescence in situ hybridization, human, human tissue, International Prognostic Scoring System, major clinical study, male, overall survival, retrospective study, risk factor, treatment free survival, beta 2-microglobulin, chronic lymphocytic leukemia, prognosis, survival
الوصف: Chronic lymphocytic leukemia (CLL) is a disease with a highly variable clinical spectrum and prognosis, and is more common in the elderly population. The identification of high-risk patients according to prognostic factors and the application of new treatment regimens have improved survival in CLL. The purpose of our study was to examine the effects of important prognostic factors on survival in patients with CLL in our patient population. Treatment-free survival (TFS) and overall survival (OS) analyses were performed in patients diagnosed with CLL between January 2000 and June 2013 according to clinical characteristics at the time of diagnosis, bone marrow infiltration pattern, lactate dehydrogenase (LDH) and beta 2-Microglobulin levels, CD38 expression and fluorescent insitu hybridization (FISH) findings. Two hundred and forty-five patients were evaluated. Presence of initial B symptom, Rai stage>I, Binet stage B and C, diffuse infiltration of bone marrow by lymphocytes, LDH, and beta 2-Microglobulin levels above upper limit of normal (ULN), and CD38 positivity shortened both TFS and OS (p0.05). Also, age over 65 years, performance score of 2 and above, and del17p positivity shortened OS (p0.05) but did not make a statistically significant difference in TFS. In multivariate analysis, it was determined that advanced age was an independent poor prognostic factor affecting OS, and Rai stage was an independent risk factor affecting TFS (p0.05). When Rai stage was excluded, beta 2-Microglobulin and LDH were found to be negative prognostic risk factors affecting TFS independent of other factors. LDH level, which is not included in the international prognostic scoring system, was found to be a marker affecting TFS and OS in our study. © 2024 Ondokuz Mayis Universitesi. All rights reserved.
العلاقة: Journal of Experimental and Clinical Medicine (Turkey); DiÄŸer; https://hdl.handle.net/11499/57014Test; https://doi.org/10.52142/omujecm.41.1.21Test; 41; 125; 131; 2-s2.0-85189503624
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4دورية أكاديمية
المؤلفون: Özturk, SavaÅŸ, Tokgöz, Bülent, Dursun, Belda, Seyahi, Nurhan, Trabulus, Sinan, Ä°slam, Mahmud, Ayar, Yavuz, Görgülü, Numan, Gök, Mahmut, Akçalı, Esra, Bora, Feyza, Arıkan, Hakkı, Aydın, Zeki, Altun, Eda, Ahbap, Elbis, Polat, Mehmet, Soypacacı, Zeki, Gök OÄŸuz, Ebru, Çolak, Hülya, Dolarslan, MürÅŸide Esra, Helvacı, Özant, Eren, Zehra, Dheir, Hamad, Öğutmen, Melike Betül, Güven Taymez, Dilek, Gibyeli Genek, Dilek, Özkurt, Sultan, Arı Bakır, Elif, Yüksel, Enver, SahutoÄŸlu, Tuncay, Oto, Özgur Akın, Boz, GülÅŸah, Åžengül, Erkan, Kara, Ekrem, TuÄŸlular, Serhan, Koyuncu, Sümeyra, Åžahin, Ä°dris, Kurultak, Ä°lhan
مصطلحات موضوعية: lactate dehydrogenase, acute kidney failure, adult, aged, Article, causal attribution, chronic kidney failure, cohort analysis, comorbidity, coronavirus disease 2019, diabetes mellitus, disease association, disease severity, female, hazard ratio, hospital discharge, hospital patient, human, hypertension, in-hospital mortality, lactate dehydrogenase blood level, major clinical study, male, mortality rate, observational study, outcome assessment, retrospective study, sex ratio, blood, clinical trial
الوصف: Background Acute kidney injury (AKI) is common in coronavirus disease-2019 (COVID-19) and the severity of AKI is linked to adverse outcomes. In this study, we investigated the factors associated with in-hospital outcomes among hospitalized patients with COVID-19 and AKI. Methods In this multicenter retrospective observational study, we evaluated the characteristics and in-hospital renal and patient outcomes of 578 patients with confirmed COVID-19 and AKI. Data were collected from 34 hospitals in Turkey from March 11 to June 30, 2020. AKI definition and staging were based on the Kidney Disease Improving Global Outcomes criteria. Patients with end-stage kidney disease or with a kidney transplant were excluded. Renal outcomes were identified only in discharged patients. Results The median age of the patients was 69 years, and 60.9% were males. The most frequent comorbid conditions were hypertension (70.5%), diabetes mellitus (43.8%), and chronic kidney disease (CKD) (37.6%). The proportions of AKI stages 1, 2, and 3 were 54.0%, 24.7%, and 21.3%, respectively. 291 patients (50.3%) were admitted to the intensive care unit. Renal improvement was complete in 81.7% and partial in 17.2% of the patients who were discharged. Renal outcomes were worse in patients with AKI stage 3 or baseline CKD. The overall in-hospital mortality in patients with AKI was 38.9%. In-hospital mortality rate was not different in patients with preexisting non-dialysis CKD compared to patients without CKD (34.4 versus 34.0%, p = 0.924). By multivariate Cox regression analysis, age (hazard ratio [HR] [95% confidence interval (95%CI)]: 1.01 [1.0–1.03], p = 0.035], male gender (HR [95% CI]: 1.47 [1.04–2.09], p = 0.029), diabetes mellitus (HR [95%CI]: 1.51 [1.06–2.17], p = 0.022) and cerebrovascular disease (HR [95%CI]: 1.82 [1.08–3.07], p = 0.023), serum lactate dehydrogenase (greater than two-fold increase) (HR [95%CI]: 1.55 [1.05–2.30], p = 0.027) and AKI stage 2 (HR [95%CI]: 1.98 [1.25–3.14], p = 0.003) and stage 3 (HR [95%CI]: 2.25 ...
العلاقة: PLoS ONE; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1371/journal.pone.0256023Test; https://hdl.handle.net/11499/47658Test; 16; 8 August; 2-s2.0-85112344732
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5دورية أكاديمية
المؤلفون: Koseler, Aylin, Arslan, Idris, Sabirli, Ramazan, Zeytunluoglu, Ali, Kilic, Oguz, Kilic, Ismail Dogu
مصطلحات موضوعية: coronary artery disease, lactate dehydrogenase, lipids, mannose levels, Alpha-D-Mannose
الوصف: Aim: Nondiabetic patients have been studied to determine whether modest elevations in plasma mannose levels may be associated with a greater incidence of coronary artery disease (CAD). Materials ; methods: The plasma mannose, lipids (triglyceride, low-density lipoprotein, high-density lipoprotein, very low-density lipoprotein) and lactate dehydrogenase levels were successfully evaluated with respect to subsequent CAD using records of 120 nondiabetic patients and 120 healthy volunteers. CAD was identified from myocardial infarction and new diagnoses of angina. Results: Of 120 patients studied, the plasma mannose, triglyceride, lactate dehydrogenase and very low-density lipoprotein levels of patients were significantly higher than control groups. Conclusion: Our findings showed that elevated baseline mannose in plasma was associated with a progressive risk of CAD with time.
العلاقة: Biomarkers In Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.2217/bmm-2020-0468Test; https://hdl.handle.net/11499/46479Test; 15; 12; 1035; 1042; 2-s2.0-85112227131; WOS:000675419100001
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6دورية أكاديمية
المؤلفون: Kosekli, M.A., Ozmen, Ö., Sahinduran, S., Herek, Özkan
مصطلحات موضوعية: Pancreatitis, acute necrotizing, Rats, Wistar, Taurocholic Acid, Certolizumab Pegol, 3,4 methylenedioxyamphetamine, amylase, lactate dehydrogenase, monoclonal antibody, triacylglycerol lipase, tumor necrosis factor, immunosuppressive agent, acute hemorrhagic pancreatitis, amylase blood level, animal experiment, Article, controlled study, enzyme activity, enzyme blood level, fat necrosis, histopathology, Animals, Disease Models, Animal, Immunosuppressive Agents, immunohistochemistry, lactate dehydrogenase blood level, male, nonhuman
الوصف: OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor ?, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four groups. Group I was the control group and no medication administered to this group. Group II was the Certolizumab group, and 100 ml/kg serum physiologic administered into the biliopancreatic duct and a single dose of 10 µg Certolizumab was simultaneously administered intraperitoneally. Acute pancreatitis was induced with a retrograde injection of 3% Na taurocholate into the common biliopancreatic duct in the study (Group III) and treatment (Groups IV) groups. Rats were sacrificed 72 hours later. Serum amylase, lipase, lactate dehydrogenase activities, along with pancreatic histo-pathology, were examined. RESULTS: Certolizumab treatment significantly decreased serum amylase, lipase, and LDH levels; histopathologically edema, hemorrhage, parenchymal necrosis, fat necrosis, and infiltration scores; immunohistochemically MDA, MPO, TNF-? and Caspase-3 activity. CONCLUSION: The results support the idea that certolizumab might be beneficial for the severity of AP. © 2019 Associacao Medica Brasileira. All rights reserved.
العلاقة: Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/30272Test; https://doi.org/10.1590/1806-9282.65.2.204Test; 65; 204; 210; 2-s2.0-85063287379; WOS:000461474100019
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7دورية أكاديمية
المؤلفون: Köseler, Aylin, Ma, F., Kılıç, Ä°smail DoÄŸu, Morselli, M., Kilic, O., Pellegrini, M.
مصطلحات موضوعية: acyl coenzyme A synthetase medium chain family member 5, AFG3 like matrix AAA peptidase subunit 2, apolipoprotein B, aspartate aminotransferase, Humans, Male, Myocardial Infarction, Phenotype, Prognosis, Promoter Regions, Genetic, Twins, Monozygotic, Cardiovascular disease, DNA methylation, Epigenetics, acyl coenzyme A synthetase family member 3, acyl coenzyme A synthetase medium chain family member 2A, carboxylesterase 1, carboxylesterase 1 pseudogene 1, creatine kinase, enzyme, genomic DNA, hydrolase, iron sulfur cluster assembly enzyme, lactate dehydrogenase, lipid droplet associated hydrolase, microsomal triglyceride transfer protein, SEC14 like lipid binding 2, unclassified drug
الوصف: Background/Aim: This study aimed to measure the DNA methylation state of thousands of CpG islands in the blood of two monozygotic twins that were discordant for cardiovascular disease (CVD). Twin 1 had suffered myocardial infarction, while the other was healthy. Patients and Methods: Since the aim of this study was to identify differentially methylated regions which might act as potential markers, reduced-representation bisulfite libraries were used for whole-genome methylation analysis. Results: According to the analysis, 11 genes lipid droplet associated hydrolase (LDAH), apolipoprotein B (APOB), acyl-CoA synthetase medium chain family member 2A (ACSM2A), acyl-CoA synthetase medium chain family member 5(ACSM5), acyl-CoA synthetase family member 3 (ACSF3), carboxylesterase 1 (CES1), carboxylesterase 1 pseudogene 1 (CES1P1), AFG3 like matrix AAA peptidase subunit 2 (AFG3L2), iron-sulfur cluster assembly enzyme (ISCU), SEC14 like lipid binding 2 (SEC14L2) and microsomal triglyceride transfer protein (MTTP) were all hypomethylated in DNA from twin 2, the unaffected twin. Methylation changes were observed at different multiple loci between the twins, suggesting loci that are affected by disease status in identical genetic backgrounds. Conclusion: This twin study may contribute significantly to the understanding of the genetic basis of CVD and resulting myocardial infarction. This approach may allow identification of possible target loci associated with aberrant epigenetic regulation in CVD. © 2020 International Institute of Anticancer Research. All rights reserved.
العلاقة: In Vivo; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/37524Test; https://doi.org/10.21873/invivo.11782Test; 34; 361; 367; 2-s2.0-85077264159; WOS:000504753200044
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8دورية أكاديمية
المؤلفون: Herek, Duygu, Ufuk, Furkan, Çallı Demirkan, NeÅŸe
مصطلحات موضوعية: bilirubin glucuronide, Female, Langerhans cell histiocytosis, liver function, liver parenchyma, lung nodule, medical history, aspartate aminotransferase, fluorodeoxyglucose f 18, gamma glutamyltransferase, lactate dehydrogenase, abdomen, adult, body weight loss, brain cortex lesion, case report, cell infiltration, clinical article, clinical feature, computer assisted tomography, dermis, diffusion weighted imaging, epigastric pain, fatigue, histiocyte, human, inflammatory cell, jaundice, kidney, kidney injury
الوصف: Not Available
العلاقة: DiÄŸer; https://hdl.handle.net/11499/30129Test; https://doi.org/10.1111/jgh.14598Test; 34; 1129; 2-s2.0-85062359497; WOS:000475990100002
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9مراجعة
مصطلحات موضوعية: Ischemic heart disease, Biomarker, Myocardial infarction, Postmortem biochemistry, Sudden cardiac death, atrial natriuretic factor, biochemical marker, biological marker, brain natriuretic peptide, copeptin, creatine kinase, fatty acid binding protein 3, ischemia modified albumin, lactate dehydrogenase, myoglobin, myosin, pentraxin 3, pregnancy associated plasma protein A, troponin T, acute heart infarction, autopsy, biochemistry, body fluid, clinical classification, clinical practice, controlled study, death, electrocardiogram, electrocardiography, heart infarction
الوصف: Ischemic heart disease (IHD) is one of the leading causes of morbidity and sudden cardiac death worldwide and is an important public health problem. The presence of ischemia in clinical applications can be detected by ECG, biochemical markers, and radiological methods. Myocardial infarction is also frequently encountered in forensic autopsies. Postmortem diagnosis is determined as a result of histopathological examinations and additional exclusionary examinations (toxicology, microbiology, etc.). However, routine histopathological examinations are insufficient, especially when death occurs in the early period of ischemia. It creates a problem for forensic pathologists and forensic medicine specialists in such cases of sudden cardiac death. Postmortem biochemistry is one of the important and promising disciplines in which forensic applications work in order to diagnose these cases correctly. The issue of whether biomarkers used in the diagnosis of myocardial infarction in clinical studies can be used reliably in postmortem cases has been discussed by forensic medicine researchers for some time. This manuscript aims to review and summarize biomarkers belonging to various categories that have been studied in IHD-related deaths, in biological fluids taken at autopsy, or in animal experiments. Our study shows that the postmortem use of biochemical markers in the diagnosis of IHD yields promising results. However, it should not be forgotten that postmortem biochemistry is different from clinical applications due to its dynamics and that the body causes unpredictable changes in markers in the postmortem process. Therefore, comprehensive studies are needed to evaluate the postmortem stability of these markers in different biological fluids, their significance among various causes of death, and whether they are affected by any variable (Cardiopulmonary resuscitation, Postmortem interval, medications, etc.) before they are routinely applied. It is suggested by the authors that the cut-off values of biomarkers whose ...
العلاقة: Journal of Forensic and Legal Medicine; DiÄŸer; https://hdl.handle.net/11499/54848Test; https://doi.org/10.1016/j.jflm.2023.102599Test; 100; 2-s2.0-85174019216; WOS:001097202200001
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10دورية أكاديمية
المؤلفون: Kösekli, M.A., Ozmen, O., Sahinduran, S., Yilmaz, Mustafa, Çobankara, Veli, Sungurtekin, UÄŸur
مصطلحات موضوعية: certolizumab, acute pancreatitis, cerulein, pathology, rat, amylase, caspase 3, certolizumab pegol, ceruletide, lactate dehydrogenase, malonaldehyde, myeloperoxidase, triacylglycerol lipase, tumor necrosis factor, amylase blood level, animal experiment, animal model, animal tissue, Article, bleeding, controlled study, disease severity, drug effect, edema, fat necrosis, hyperemia, lactate dehydrogenase blood level, male, neutrophil chemotaxis, nonhuman
الوصف: Objectives To evaluate the effects of certolizumab, a pegylated monoclonal antibody to tumor necrosis factor ? (TNF-?), on experimentally induced acute pancreatitis. Methods Healthy Wistar Albino male rats (n = 36) were randomly divided into 4 groups (9 rats in each group): group 1, control group; group 2, certolizumab group; group 3, cerulein group; and group 4, cerulein + certolizumab group. Acute edematous pancreatitis was induced via intraperitoneal injection of 80-µg/kg cerulein (20 µg/kg, 4 times at 1-hour intervals) in groups 3 and 4. Certolizumab (10 µg) was intraperitoneally administered in groups 2 and 4. Serum levels of amylase, lipase, TNF-?, and lactate dehydrogenase were evaluated. Histopathology and immunohistochemistry of the pancreatic tissue for assessing the activities of malondialdehyde, myeloperoxidase, TNF-?, and caspase-3 were also performed after 72 hours. Results Certolizumab treatment significantly decreased the serum levels of amylase, lipase, and lactate dehydrogenase. Histopathological edema, hemorrhage, parenchymal necrosis, and infiltration scores were also decreased, along with a decrease in malondialdehyde, myeloperoxidase, TNF-?, and caspase-3 activities. Conclusion This study suggests that certolizumab is a beneficial treatment mode for reducing the severity of acute pancreatitis. Copyright © 2016 Wolters Kluwer Health, Inc. All rights reserved.
العلاقة: Pancreas; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/9456Test; https://doi.org/10.1097/MPA.0000000000000660Test; 45; 1120; 1125; 2-s2.0-84966714181; WOS:000382322200010