المؤلفون: Ichihara, K., Ozarda, Y., Ari, Z., Taneli, F., Coker, C., Aybek, H., Aslan, Diler

مصطلحات موضوعية: common reference intervals, biochemical parameters, multicenter study, regional differences, Turkey, alanine aminotransferase, albumin, alkaline phosphatase, amylase, aspartate aminotransferase, bilirubin, bilirubin glucuronide, calcium, chloride, creatine kinase, creatinine, gamma glutamyltransferase, glucose, high density lipoprotein, lactate dehydrogenase, low density lipoprotein, magnesium, nitrogen, phosphate, potassium, protein, sodium, triacylglycerol, uric acid, inorganic compound

الوصف: Background: A nationwide multicenter study was organized to establish reference intervals (RIs) in the Turkish population for 25 commonly tested biochemical analytes and to explore sources of variation in reference values, including regionality. Methods: Blood samples were collected nationwide in 28 laboratories from the seven regions (?400 samples/region, 3066 in all). The sera were collectively analyzed in Uludag University in Bursa using Abbott reagents and analyzer. Reference materials were used for standardization of test results. After secondary exclusion using the latent abnormal values exclusion method, RIs were derived by a parametric method employing the modified Box-Cox formula and compared with the RIs by the non-parametric method. Three-level nested ANOVA was used to evaluate variations among sexes, ages and regions. Associations between test results and age, body mass index (BMI) and region were determined by multiple regression analysis (MRA). Results: By ANOVA, differences of reference values among seven regions were significant in none of the 25 analytes. Significant sex-related and age-related differences were observed for 10 and seven analytes, respectively. MRA revealed BMI-related changes in results for uric acid, glucose, triglycerides, high-density lipoprotein (HDL)-cholesterol, alanine aminotransferase, and ?-glutamyltransferase. Their RIs were thus derived by applying stricter criteria excluding individuals with BMI >28 kg/m2. Ranges of RIs by non-parametric method were wider than those by parametric method especially for those analytes affected by BMI. Conclusions: With the lack of regional differences and the well-standardized status of test results, the RIs derived from this nationwide study can be used for the entire Turkish population. © by De Gruyter 2014.

العلاقة: Clinical Chemistry and Laboratory Medicine; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7859Test; https://doi.org/10.1515/cclm-2014-0228Test; 52; 12; 1823; 1833; 2-s2.0-84910130520; WOS:000345023500026

الإتاحة: https://doi.org/10.1515/cclm-2014-0228Test
https://hdl.handle.net/11499/7859Test

المؤلفون: Özgürler, Funda, Balcı, Yasemin Işık, Tan, M., Polat, Aziz, KoçyiÄŸit, Ali

مصطلحات موضوعية: Hereditary spherocytosis, Childhood, Wandering spleen, bilirubin glucuronide, ferritin, hemoglobin, lactate dehydrogenase, paracetamol, abdominal mass, abdominal pain, adolescent, article, case report, colic, computer assisted tomography, erythrocyte, family history, female, follow up, hematocrit, human, hyperbilirubinemia, leukocyte, low drug dose, mean corpuscular hemoglobin, mean corpuscular volume, osmotic fragility, thrombocyte, treatment response, vital sign

الوصف: Not Available

العلاقة: Pediatric Hematology and Oncology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7421Test; https://doi.org/10.3109/08880018.2013.831150Test; 31; 101; 103; 2-s2.0-84893326960; WOS:000331063500013

الإتاحة: https://doi.org/10.3109/08880018.2013.831150Test
https://hdl.handle.net/11499/7421Test

المؤلفون: Onat, A.M., Kisacik, B., Kasifoglu, T., Pehlivan, Y., Pamuk, O.N., Dalkilic, E., Donmez, S.

مصطلحات موضوعية: arthritis, male, middle aged, multicenter study, Paraneoplastic Syndromes, pathology, predictive value, treatment outcome, Turkey, Adult, Malignancy, Early rheumatoid arthritis, Paraneoplastic arthritis, antirheumatic agent, biological marker, cyclic citrullinated peptide, cyclopeptide, lactate dehydrogenase, rheumatoid factor, aged, Antirheumatic Agents, Biological Markers, Case-Control Studies, Diagnosis, Differential, Female, Peptides, Cyclic, Predictive Value of Tests, Rheumatoid

الوصف: Objectives: Paraneoplastic arthritis (PA) may mimic rheumatic diseases. While presenting the demographic and laboratory features of the patients diagnosed with PA, this study also aims to provide possible appropriate tools to differentiate the PA cases from early rheumatoid arthritis (ERA). Methods: Sixty-five patients with PA (male/female: 43/22) from 15 different rheumatology clinics and 50 consecutive patients with ERA (male/female: 13/37) fulfilling the 2010 American College of Rheumatology (ACR) criteria for the diagnosis if the RA from Gaziantep Rheumatology Early Arthritis Trial (GREAT) as controls who were diagnosed at least 12 months before, were enrolled into study. Results: Mean ages of the patients with PA and ERA were 50.2 ± 15.3, and 42.7 ± 12.3, respectively, and the mean ages of the patients with PA were significantly higher than the ERA. Unlike the ERA patients, in our case series PA was predominantly observed among males. Oligoarthritis was significantly higher in solid tumors in contrast to ERA (P = 0.001). Polyarthritis and symmetric arthritis were significantly higher in the ERA group in contrast to all malignancies (P = 0.001). Rheumatoid factor (RF) and anticyclic citrullinated peptide antibody (anti-CCP) positivity were significantly higher in the ERA group (each P = 0.001). Lactic dehydrogenase levels of hematologic malignancies were significantly higher than other groups (each, P = 0.001). Conclusions: ERA patients had more symmetric joint involvement than PA; laboratory markers could be also an alternative where there is high RF and anti-CCP positivity with antibody levels among the ERA patients. Finally, the demographic features can be used as differentiating factors; ERA was seen predominantly among females aged 40-59 years which refers to young adults. © 2014 Asia Pacific League of Associations for Rheumatology and Wiley Publishing Asia Pty Ltd.

العلاقة: International Journal of Rheumatic Diseases; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7375Test; https://doi.org/10.1111/1756-185X.12277Test; 17; 640; 645; 2-s2.0-84933520257; WOS:000344362300007

الإتاحة: https://doi.org/10.1111/1756-185X.12277Test
https://hdl.handle.net/11499/7375Test

المؤلفون: Iwasaki, K., Egashira, N., Akiyoshi, Y., Takagaki, Y., Hatip-Al-Khatib, Ä°zzettin., Mishima, K., Kurauchi, K.

مصطلحات موضوعية: Alzheimer's disease, ß-amyloid, Lactate dehydrogenase (LDH) activity, Lipid peroxidation, Neuronal damage, Toki-shakuyaku-san, amyloid beta protein[25-35], herbaceous agent, lactate dehydrogenase, malonaldehyde, toki shakuyaku san, unclassified drug, Alzheimer disease, animal cell, article, brain cell, concentration response, controlled study, nerve cell culture, nerve degeneration, nerve injury, nonhuman, rat, senile plaque, traditional medicine, Amyloid beta-Protein, Animals, Apoptosis, Cerebral Cortex, Dose-Response Relationship

الوصف: Amyloid ß protein (Aß) is the major component of senile plaques, the pathological hallmark of the neurodegeneration associated with Alzheimer's disease (AD). This study investigated the effect of Toki-shakuyaku-san (TSS), a traditional medicine, on Aß25-35-induced neuronal death and lipid peroxidation assessed by measuring lactate dehydrogenase (LDH) and malondialdehyde (MDA), respectively. Aß25-35 at 10 µM induced neuronal damage and increased the LDH and MDA. TSS at concentrations of 100 and 300 µg/mL significantly reduced the Aß25-35-induced neuronal death and the lipid peroxidation. These results suggest that TSS has a protective effect against Aß25-35-induced neuronal damage. TSS may be beneficial for the treatment of AD. Copyright © 2005 John Wiley ;amp; Sons, Ltd.

العلاقة: Phytotherapy Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/4876Test; https://doi.org/10.1002/ptr.1671Test; 19; 450; 453; 2-s2.0-24644504769; WOS:000231575700016

الإتاحة: https://doi.org/10.1002/ptr.1671Test
https://hdl.handle.net/11499/4876Test

المؤلفون: Demir, Süleyman, Yılmaz, Mustafa, Herek, Özkan, Akbulut, Metin

مصطلحات موضوعية: Diagnosis, Alkaline phosphatase, IgA, Immunoglobulin A, Intestinal ischemia, Lactate dehydrogenase, animal model, animal tissue, article, controlled study, immune response, intestine ischemia, male, nonhuman, priority journal, rat, Animals, Intestines, Ischemia, L-Lactate Dehydrogenase, Models, Animal, Rats

الوصف: Many biochemical markers have been investigated in intestinal ischemia. However, the effects of intestinal ischemia on the level of serum immunoglobulin A (IgA) has apparently not been investigated in the literature, although the gastrointestinal system is one of the main sources of serum IgA. The aim of our study was to evaluate the changes of serum IgA levels during intestinal ischemia of varying duration in rats. Group 1 (n = 5) was created for control purposes, including the detection of the baseline values and the effects of the anesthetic agents. Group 2 (n = 20) rats underwent sham laparotomy. Group 3 (n = 20) had 50% of small intestine ischemia by the strangulated obstruction model. Serum samples were obtained by cardiac puncture 1 h after anesthetic agents were given in group 1. On the other hand, serum and intestine samples were obtained at 1 (T1, n= 5), 2 (T2, n= 5), 4 (T4, n=5) and 6 (T6, n= 5) h after the operation in groups 2 and 3. The levels of serum IgA, lactic dehydrogenase (LDH) and alkaline phosphatase (ALP) were determined. Pathologic specimens were graded in a masked manner. IgA levels were abruptly decreased to 8.49 ± 1.58 mg/dl in rats with intestinal ischemia at 1 h after the operation. This decrease in serum IgA at T1 in group 3 was statistically significant compared with the control and sham-operated groups (18.80 ± 1.15 mg/dl, 22.07 ± 1.54 mg/dl, respectively; P0.01). On the other hand, IgA levels were significantly elevated at T2 in the sham-operated group compared with control and intestinal ischemia groups (26.99 ± 2.96 mg/dl, 18.80 ± 1.15 mg/dl, 14.354 ± 2.62 mg/dl, respectively; P 0.05). The serum IgA levels decreased to above baseline values at T6 in group 2 (19.60 ± 2.78 mg/dl), while they increased to below baseline values in group 3 (17.60 ± 1.28 mg/dl). In group 3, IgA levels were elevated to baseline values, while a significant ischemia occurred at 4 and 6 h after operation. These results suggested that serum IgA is affected earlier by intestinal ischemia and ...

العلاقة: Pediatric Surgery International; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/5215Test; https://doi.org/10.1007/s00383-003-1051-0Test; 19; 601; 604; 2-s2.0-0242389631; WOS:000186494700009

الإتاحة: https://doi.org/10.1007/s00383-003-1051-0Test
https://hdl.handle.net/11499/5215Test

المؤلفون: Güçtürk, I., Kaya, Burçin, Halis, Hülya, Karaca, Abdullah, Akın, Mehmet, Küçüktaşçı, Kazım

مصطلحات موضوعية: Brucellosis, Anemia, hemolytic, autoimmune, Coombs' test, alanine aminotransferase, amoxicillin, aspartate aminotransferase, bilirubin, complement component C3d, cotrimoxazole, creatinine, gentamicin, hemoglobin, immunoglobulin G, lactate dehydrogenase, nitrogen, prednisolone, urea, acute kidney failure, agglutination test, case report, alanine aminotransferase blood level, antibiotic therapy, article, aspartate aminotransferase blood level, bilirubin blood level, Brucella, child, complement blood level

الوصف: Human brucellosis is a multisystem disease with a wide spectrum of clinical manifestations. Brucellosis can mimic several primary hematological diseases. Several non-specific hematologic abnormalities have been reported with brucellosis including anemia, leukopenia, thrombocytopenia and pancytopenia. We discussed about steroid therapy and described a child case of acute brucellosis presenting with Coombs-positive AIHA. A 3.5-year-old girl was admitted to our hospital by pallor, palpitation, fever , scleral icterus. Laboratory test showed hemoglobin 7.4 g/dL, direct Coombs IgG plus C3d test strongly positive (3+). Serology for Brucella was strongly positive (Wright agglutination reaction [1/2560], coombs agglutination reaction [1/5120]). The differential diagnosis child of Coombs-positive AIHA should include brucellosis, especially in patients living in endemic areas.Early diagnosis and treatment of disease at AIHA depentdent brucellos is important because of they could be determined to severe acute hemolysis.

العلاقة: Gazzetta Medica Italiana Archivio per le Scienze Mediche; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/8691Test; 171; 81; 84; 2-s2.0-84858732760

الإتاحة: https://hdl.handle.net/11499/8691Test

المؤلفون: TekekoÄŸlu, Selma, Ozmen, O., Sahinduran, Åž., Buyukoglu, T., Yılmaz, Mustafa, Herek, Özkan

مصطلحات موضوعية: adalimumab, acute necrotic pancreatitis, pathology, rat, amylase, lactate dehydrogenase, malonaldehyde, myeloperoxidase, taurocholic acid, acute pancreatitis, animal experiment, animal model, animal tissue, article, biliopancreatic bypass, controlled study, drug efficacy, enzyme activity, enzyme blood level, histopathology, male, nonhuman, priority journal, Acute Disease, Amylases, Animals, Anti-Inflammatory Agents, Antibodies, Monoclonal, Injections

الوصف: Objectives: In this study, the effects of adalimumab (ADA), a fully humanized IgG1 monoclonal antibody to tumor necrosis factor ?, on experimentally acute pancreatitis (AP) were examined. Methods: Healthy Wistar rats (n = 32) were randomly divided into 4 groups: group 1, AP; group 2, AP + ADA; group 3, control (physiologic saline), and group 4, physiologic saline + ADA (n = 8/group). Acute pancreatitis was induced with a retrograde injection of 3% sodium (Na)-taurocholate into the common biliopancreatic duct. Adalimumab was simultaneously administered at 50 mg/kg intraperitoneally for groups 2 and 4. Physiologic saline was administered instead of Na-taurocholate for non-AP groups. After 24 hours, serum amylase, lactate dehydrogenase, pancreatic myeloperoxidase, and malondialdehyde activities, along with pancreatic histopathology, were examined. Results: Adalimumab treatment significantly decreased serum amylase activity (AP, 2778.25 ± 298.80; AP + ADA, 2143.13 ± 221.69; control, 1541.00 ± 148.39; ADA, 1143.00 ± 256.30 U/L; P 0.001), lactate dehydrogenase activity (AP, 2978.37 ± 364.65; AP + ADA, 2582.75 ± 164.23; control 931.25 ± 135.93; ADA, 582.62 ± 99.37 U/L; P 0.001), myeloperoxidase activity (AP, 1.44 ± 0.20; AP + ADA, 0.86 ± 0.01; control, 0.60 ± 0.17; ADA, 0.41 ± 0.00 U/g of wet tissue; P 0.001), malondialdehyde activity (AP, 16.94 ± 3.98; AP + ADA, 7.66 ± 2.27; control, 9.07 ± 1.00; ADA, 3.58 ± 0.30 nmol/g; P 0.01), and total histopathologic scores (AP, 2.75 ± 0.16; AP + ADA, 1.50 ± 0.19; control, 0.00 ± 0.00; ADA, 0.00 ± 0.00; P 0.001). Conclusions: These results support the idea that adalimumab might be beneficial for severity of AP. © 2010 by Lippincott Williams ; Wilkins.

العلاقة: Pancreas; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/6259Test; https://doi.org/10.1097/MPA.0b013e3181dec1a6Test; 39; 1238; 1242; 2-s2.0-78049281359; WOS:000282946600020

الإتاحة: https://doi.org/10.1097/MPA.0b013e3181dec1a6Test
https://hdl.handle.net/11499/6259Test

المؤلفون: Kelten, Canan., Kabukçu, Sibel., Åžen, Nilay., Teke, Zafer., Düzcan, Ender., Erdem, Ergün., Yaren, Arzu.

مصطلحات موضوعية: Lymphadenopathy, Breast involvement, Lymphoma, Skin, carboplatin, CD30 antigen, cisplatin, complement component C3d receptor, cyclophosphamide, cytarabine, dexamethasone, doxorubicin, eosin, etoposide, formaldehyde, hematoxylin, hemoglobin, ifosfamide, lactate dehydrogenase, paraffin, prednisone, vincristine, adult, article, aspiration biopsy, axillary lymph node, blood examination, breast carcinoma, cancer chemotherapy, cancer growth

الوصف: Non-Hodgkin lymphoma of the breast is a rare malignancy and present with almost equal frequency either as a primary or a secondary disease. Survival is poor in most cases of secondary breast lymphoma because of their advanced stage. We report a 35-year-old woman presenting with dyspnea as well as swelling, tenderness, and ruddiness in the left breast with non-cyclic pain for several months and maculopapular skin eruption in the same breast. Physical examination revealed fixed lymphadenopathies in both axillary regions. Radiologic evaluations (bilateral mammaograpy and ultrasonography) showed skin thickening in the left breast, asymmetrical densities in both breasts, and confirmed lymphadenopathies in the axillary regions. Excisional biopsies were performed to the left axillary lymph nodes and the breast skin eruptions. The histologic and immunohistochemical features were diagnosed as an ALK (-) anaplastic large cell lymphoma. A Computed Tomography examination was performed for staging the lymphoma and then chemotherapy was started. Thirty months after the diagnosis, the patient is still alive with disease. Because of the presence of systemic symptoms such as skin involvement and generalized lymphadenopathies (mediastinal, axillary or cervical), T cell lymphoma cases with breast involvement could mimic the clinical presentation of inflammatory breast carcinoma. Pathologic examination is needed for the correct diagnosis. © 2008 Springer-Verlag.

العلاقة: Archives of Gynecology and Obstetrics; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/6750Test; https://doi.org/10.1007/s00404-008-0869-zTest; 280; 149; 152; 2-s2.0-67649643671; WOS:000266434300029

الإتاحة: https://doi.org/10.1007/s00404-008-0869-zTest
https://hdl.handle.net/11499/6750Test

المؤلفون: Yasa, H., Ergunes, K., Ortac, R., Karahan, N., Ozbek, C., Yakut, N., Emrecan, Bilgin.

مصطلحات موضوعية: ischemia, iloprost, levosimendan, lung-reperfusion damage, creatine kinase, lactate dehydrogenase, malonaldehyde, potassium, sodium, animal experiment, animal model, animal tissue, article, blood pH, continuous infusion, controlled study, drug effect, drug tolerability, female, femoral artery, histopathology, limb ischemia, loading drug dose, lung hemodynamics, lung injury, male, nonhuman, priority journal, rabbit, reperfusion injury

الوصف: Background: The aim of this study was to clarify whether levosimendan could prevent lung tissue injury from limb ischemia/reperfusion. Methods: The common femoral arteries of 50 New Zealand white rabbits, both male and female, each weighing about 3 kg, were clamped and 1 h of ischemia followed by 4 h of reperfusion. In an attempt to decrease reperfusion injury, the rabbits were given levosimendan in Group A. In Group B, iloprost was infused at the same period. A similar value of saline solution was given in the control group, Group C correspondingly. Levosimendan and iloprost were given together the Group E, and Group D was sham group without medication and ischemia. Blood pH, pO2, pCO2, HCO3, Na, K, creatine phosphokinase, lactate dehydrogenase values were determined at the end of the reperfusion period. Malondialdehyde (MDA) was measured in plasma and lung as an indicator of free radicals. Hemodynamics parameters were noted for each group. After the procedure, left lung tissues were taken for histopathologic study. Results: Blood PO2 and HCO3 levels were significantly higher (P 0.05) and creatine phosphokinase, lactate dehydrogenase, and MDA levels were significantly lower (P 0.05) in Groups A, B, D, and E compared with Group C. Similarly, the MDA levels in the lung tissue and plasma levels were significantly lower in the treatment groups compared with the control group (P 0.05). Lung damage was significantly higher in Group C. There was no significant difference between groups in other parameters. Conclusions: The results suggest that levosimendan and iloprost are useful for attenuating oxidative lung damage occurring after a period of limb ischemia/reperfusion. © 2008 Elsevier Inc. All rights reserved.

العلاقة: Journal of Surgical Research; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7150Test; https://doi.org/10.1016/j.jss.2007.08.002Test; 147; 138; 142; 2-s2.0-43049119601; WOS:000255668500020

الإتاحة: https://doi.org/10.1016/j.jss.2007.08.002Test
https://hdl.handle.net/11499/7150Test

المؤلفون: Bagci, C., Can, S., Ozaslan, M., Bozkurt, Ali Ä°hsan., Cengiz, B., Çakmak, E.A., KocabaÅŸ, R.

مصطلحات موضوعية: Biochemical parameters, Battery workers, Liver function, Muffler repair workers, Occupational lead exposure, Toxicity, alanine aminotransferase, aspartate aminotransferase, bilirubin, gamma glutamyltransferase, lactate dehydrogenase, lead, lipid, adult, article, blood, chemically induced disorder, drinking behavior, human, liver disease, liver function test, male, metabolism, middle aged, motor vehicle, occupational disease, occupational exposure, risk factor, smoking, Alanine Transaminase

الوصف: The effect of occupational lead exposure on the liver function and on the blood biochemical parameters among the battery workers and the muffler repair workers was studied. The study included 22 battery and 38 muffler repair workers. Whole blood lead levels were determined by atomic absorption spectrophotometers. Total protein, albumin, globulin, cholesterol, triglyceride, total bilirubin, aspartate transaminase (AST), alanine transaminase (ALT), gamma glutamyltransferase (GGT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP) levels were determined in the serum by spectrophotometry. The blood lead levels of the battery workers, muffler repair workers, and the controls were found to be 36.83±8.13 µg/dL, 26.99±9.42 µg/dL, and 14.81±3.01 µg/dL, respectively. Blood lead levels of the workers were significantly higher than those of controls (p0.001). The lead level of the battery workers was also significantly higher than that of muffler repair workers (p0.001). Although, statisticly significant, higher blood lead levels are not related to toxicity for battery and muffler repair workers. Total protein, globulin, cholesterol, LDH, and ALP levels were within normal levels, however, they were slightly higher than the control levels. Increased LDH among the workers seems to be related rather to other causes than to the liver injury. © 2008 Akadémiai Kiadó.

العلاقة: Acta Physiologica Hungarica; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/7007Test; https://doi.org/10.1556/APhysiol.95.2008.4.6Test; 95; 395; 403; 2-s2.0-54949135727; WOS:000260825300006

الإتاحة: https://doi.org/10.1556/APhysiol.95.2008.4.6Test
https://hdl.handle.net/11499/7007Test