دورية أكاديمية
Interleukin-1 gene (IL-1) polymorphism in patients with Behcet's Disease, and its relationship with disease manifestations
| العنوان: | Interleukin-1 gene (IL-1) polymorphism in patients with Behcet's Disease, and its relationship with disease manifestations |
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| المؤلفون: | Ozkan, Umit, Ulutas, Firdevs, Cobankara, Veli, Tepeli, Emre |
| بيانات النشر: | Sage Publications Inc |
| سنة النشر: | 2022 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Behcet's disease, IL-1 gene polymorphism, IL-1 alpha, IL-1 beta, IL-1 receptor antagonist (IL-1ra), Turkish Patients, Association, Susceptibility |
| الوصف: | Objective: The objective of this study was to investigate whether interleukin-1 (IL-1) gene polymorphisms are associated with susceptibility to Behcet's disease (BD) and clinical manifestations of the disease. Methods: In this cross-sectional study, we enrolled 110 patients with BD and age-and gender-matched 120 healthy controls. Five polymorphic regions of the IL-1 gene including rs 1800587 (IL1A-889 C/T), rs 2234650 (IL1R1), rs 16944 (IL1B-511 C/T), rs 315952 (IL1RN), and rs 1143634 (IL1B-3954 C/T) were analyzed by using the real-time polymerase chain reaction system. Allele frequencies and genotypes were compared between groups. p = 0.05 was accepted as statistically significant. Results: The mean age of the patients with BD was 41 +/- 12.4 years. The two groups were similar in terms of the age and gender distribution. The vast majority of BD patients had mucocutaneous involvement. The mean disease duration was 83.7 +/- 67.8 months among the patients. The frequencies of each polymorphism in the IL-1 gene were similar between patients with BD and healthy controls. Conclusion: The frequencies of variable IL-1 gene polymorphisms were similar between patients with BD and healthy controls. ; project of the Pamukkale University Scientific Research Projects Coordination Unit [2014 TPF034] ; Y This study was also supported by the 2014 TPF034 project of the Pamukkale University Scientific Research Projects Coordination Unit. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1721-727X 2058-7392 |
| العلاقة: | European Journal Of Inflammation; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://doi.org/10.1177/1721727X221116698Test; https://hdl.handle.net/11499/46896Test; 20; 2-s2.0-85136852102; WOS:000846840900001 |
| DOI: | 10.1177/1721727X221116698 |
| الإتاحة: | https://doi.org/10.1177/1721727X221116698Test https://hdl.handle.net/11499/46896Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.3053F6F8 |
| قاعدة البيانات: | BASE |
| تدمد: | 1721727X 20587392 |
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| DOI: | 10.1177/1721727X221116698 |