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Contribution of heme oxygenase 2 to blood pressure regulation in response to swimming exercise and detraining in spontaneously hypertensive rats

التفاصيل البيبلوغرافية
العنوان: Contribution of heme oxygenase 2 to blood pressure regulation in response to swimming exercise and detraining in spontaneously hypertensive rats
المؤلفون: Barış, Ä°kbal Cansu, Turhan, G., Kılıç-Erkek, Özgen, Kılıç-Toprak, Emine, Abban-Mete, Gülçin, Caner, Vildan, Küçükatay, Vural
بيانات النشر: International Scientific Information, Inc.
سنة النشر: 2018
المجموعة: Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi
مصطلحات موضوعية: animal experiment, animal tissue, Article, blood gas analysis, blood pressure regulation, controlled study, endurance training, enzyme activity, essential hypertension, exercise, Heme oxygenase (Decyclizing), gene expression, histological score, immunohistochemistry, immunoperoxidase staining, Aorta, Inbred SHR, Rats, Swimming, beta actin, carbon monoxide, carboxyhemoglobin, complementary DNA, heme oxygenase 2, messenger RNA, peroxidase, heme oxygenase, adventitia, aerobic exercise, male
الوصف: Background: We aimed to determine the effects of exercise followed by detraining on systolic blood pressure (SBP), heme oxygenase 2 (HO-2) expression, and carboxyhemoglobin (COHb) concentration in spontaneously hypertensive rats (SHR) to explain the role of carbon monoxide (CO) in this process. Material/Methods: Animals were randomized into exercised and detrained groups. Corresponding sedentary rats were grouped as Time 1–2. Swimming of 60 min/5 days/week for 10 weeks was applied. Detraining rats discontinued training for an additional 5 weeks. Gene and protein expressions were determined by real-time PCR and immunohistochemistry. Results: Aorta HO-2 histological scores (HSCORE) of hypertensive rats were lower, while SBP was higher. Swimming caused enhancement of HO-2 immunostaining in aorta endothelium and adventitia of SHR. Exercise induced elevation of blood COHb index in SHR. Synchronous BP lowering effect of exercise was observed. HO-2 mRNA expression, HSCORE, and blood COHb index were unaltered during detraining, while SBP was still low in SHR. Conclusions: CO synthesized by HO-2 at least partly plays a role in SBP regulation in the SHR-and BP-lowering effect of exercise. Regular exercise with short-term pauses may be advised to both hypertensives and individuals who are at risk. © Med Sci Monit.
نوع الوثيقة: article in journal/newspaper
اللغة: English
تدمد: 1234-1010
العلاقة: Medical Science Monitor; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10675Test; https://doi.org/10.12659/MSM.908992Test; 24; 5851; 5859; 2-s2.0-85053686009; WOS:000442483900002
DOI: 10.12659/MSM.908992
الإتاحة: https://doi.org/10.12659/MSM.908992Test
https://hdl.handle.net/11499/10675Test
حقوق: open
رقم الانضمام: edsbas.D0CC776A
قاعدة البيانات: BASE
الوصف
تدمد:12341010
DOI:10.12659/MSM.908992