دورية أكاديمية
Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study
| العنوان: | Diagnostic value of combined serum biomarkers for the evaluation of liver fibrosis in chronic hepatitis C infection: A multicenter, noninterventional, observational study |
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| المؤلفون: | Turgut, Hüseyin, Köksal, I., Yilmaz, G., Parlak, M., Demirdal, T., Kinikli, S., Candan, M., Kaya, A., Akhan, Sila, Aydogdu, Ozcan, Gurbuz, Yunus, Dagli, Ozgur, Gokal, Ahmet Ali, Guner, Rahmet, Kuruuzum, Ziya, Tarakci, Huseyin, Beslen, Nuri, Erdogan, Seda, Ozdener, Fatih |
| بيانات النشر: | AVES Ä°brahim KARA |
| سنة النشر: | 2018 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | pathology, platelet count, procedures, statistics and numerical data, Female, Hepatitis C, Chronic, Humans, Liver, Liver Cirrhosis, Liver Function Tests, Male, Middle Aged, Sensitivity and Specificity, Turkey, Young Adult, APRI, Chronic hepatitis C infection, Fib-4, FibroTest, Forns index, Liver fibrosis, Non-invasive serum biomarkers, alanine aminotransferase, aspartate aminotransferase, biological marker, adult, aged, Article, aspartate aminotransferase blood level |
| الوصف: | Background/Aims: The hepatitis C virus (HCV) infection is important cause of chronic hepatitis. Liver biopsy is considered the gold standard for assessment of fibrosis but this procedure is an invasive procedure. We aimed to evaluate the diagnostic efficiency of non-invasive serum biomarkers, separately and in combinations, on liver fibrosis in treatment-naive chronic hepatitis C (CHC) patients. Materials and Methods: Two hundred and sixteen treatment-naive CHC patients were enrolled from 32 locations across Turkey in this open-labelled, non-interventional prospective observational study. FibroTest®, aspartate aminotransferase-to-platelet ratio index(APRI), aspartate aminotransferase and alanine aminotransferase ratio (AAR), fibrosis index based on four factors (FIB-4), Age-platelet(AP) index and Forns index were measured and compared with Metavir scores got from liver biopsies. Results: Data from 182 patients with baseline liver biopsy were suitable for analysis. One hundred and twenty patients (65.9%) had F0-F1 fibrosis and 62 patients (34.1%) had F2-F4 fibrosis. APRI 0.732 area under the curve(AUC) indicated advanced fibrosis with 69% sensitivity and 77% specificity. FIB-4 0.732 AUC and FibroTest 0.715 AUC indicated advanced fibrosis with 69% and 78.4% sensitivity, and 75% and 71.4% specificity, respectively. The combined use of tests also led to an increase in AUC and specificity. Combinations of FibroTest with APRI and/or FIB-4, and FIB-4 with APRI were optimal for the evaluation of liver fibrosis. Conclusion: Fibrotest, FIB-4, APRI, AP index and Forns index exhibit good diagnostic performance for determining liver fibrosis in CHC patients, and the use of at least two tests together will increase their diagnostic value still further. © Copyright 2018 by The Turkish Society of Gastroenterology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1300-4948 30249562 |
| العلاقة: | Turkish Journal of Gastroenterology; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10743Test; https://doi.org/10.5152/tjg.2018.16597Test; 29; 464; 472; 2-s2.0-85050345680; WOS:000440301200015 |
| DOI: | 10.5152/tjg.2018.16597 |
| الإتاحة: | https://doi.org/10.5152/tjg.2018.16597Test https://hdl.handle.net/11499/10743Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.1340EBAB |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13004948 30249562 |
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| DOI: | 10.5152/tjg.2018.16597 |