دورية أكاديمية
Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus
| العنوان: | Evaluation of second trimester amniotic fluid ADAMTS4, ADAMTS5, interleukin-6 and tumor necrosis factor-? levels in patients with gestational diabetes mellitus |
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| المؤلفون: | Melekoglu, R., Çiftci, Osman, Yilmaz, E., Bastemur, A.G., Celik, E. |
| بيانات النشر: | Blackwell Publishing |
| سنة النشر: | 2019 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | amnion, gestational age, human, karyotyping, pathogenesis, pregnancy diabetes mellitus, prospective study, second trimester pregnancy, amnion fluid, chemistry, metabolism, pregnancy, ADAMTS4 Protein, ADAMTS5 Protein, A Disintegrin and Metalloprotease Protein, gestational diabetes mellitus, interleukin-6, thrombospondin, tumor necrosis factor-alpha, aggrecanase 1, aggrecanase 2, interleukin 6, tumor necrosis factor, IL6 protein, TNF protein, adult, age, amniocentesis, amnion fluid analysis, Article |
| الوصف: | Aim: To test the hypothesis that altered A Disintegrin and Metalloproteinase Domains with Thrombospondins motifs (ADAMTS) is implicated in the etiopathogenesis of gestational diabetes mellitus (GDM). Methods: All pregnant women who underwent elective amniocentesis for karyotype analysis between January 1, 2016, and January 1, 2018, were included in this study. From this cohort, the study group consisting of 20 patients diagnosed with GDM was selected and compared against a control group consisting of 20 age- and body mass index (BMI)-matched patients without GDM. ADAMTS4, ADAMTS5, interleukin-6 (IL-6) and tumor necrosis factor alpha (TNF-?) levels were compared in the second trimester amniotic fluid of patients with GDM and normoglycemic pregnant women. Results: No significant differences were observed between GDM and control groups regarding age, BMI, gestational age at amniocentesis and indication for amniocentesis. Mean amniotic fluid ADAMTS4 and ADAMTS5 levels were significantly increased in the GDM group compared with the control group (253.5 ± 18.7 pg/mL and 188.5 ± 21.3 pg/mL, P 0.001; 192.9 ± 16.4 pg/mL and 154.8 ± 19.9 pg/mL, P = 0.021, respectively). Significant increases in IL-6 and TNF-? levels were also detected in the amniotic fluid of GDM patients relative to controls (136.2 ± 17.3 pg/mL and 98.3 ± 11.5 pg/mL, P 0.001; 154.2 ± 12.5 pg/mL and 86.2 ± 10.8 pg/mL, P 0.001, respectively). Conclusion: The data presented here suggest that increased levels of ADAMTS4, ADAMTS5, IL-6 and TNF-? may play an important role in the progression of GDM. © 2019 Japan Society of Obstetrics and Gynecology |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| ردمك: | 978-0-00-462919-3 0-00-462919-1 |
| تدمد: | 1341-8076 |
| العلاقة: | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/30214Test; https://doi.org/10.1111/jog.13914Test; 45; 824; 829; 2-s2.0-85059669961; WOS:000462919100008 |
| DOI: | 10.1111/jog.13914 |
| الإتاحة: | https://doi.org/10.1111/jog.13914Test https://hdl.handle.net/11499/30214Test |
| حقوق: | none |
| رقم الانضمام: | edsbas.8C581BC6 |
| قاعدة البيانات: | BASE |
| ردمك: | 9780004629193 0004629191 |
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| تدمد: | 13418076 |
| DOI: | 10.1111/jog.13914 |