دورية أكاديمية
Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy
| العنوان: | Increased expression of matrix metalloproteinase-9 in patients with temporal lobe epilepsy |
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| المؤلفون: | Acar, Göksemin, Tanriover, G., Acar, Feridun, Demir, R. |
| بيانات النشر: | Turkish Neurosurgical Society |
| سنة النشر: | 2015 |
| المجموعة: | Pamukkale University Repository / Pamukkale Üniversitesi Açık Erişim Arşivi |
| مصطلحات موضوعية: | Hippocampal sclerosis, Matrix metalloproteinase-9, Temporal lobe epilepsy, Young Adult, gelatinase A, gelatinase B, TIMP1 protein, human, TIMP2 protein, tissue inhibitor of metalloproteinase 1, tissue inhibitor of metalloproteinase 2, adult, biosynthesis, brain, enzymology, Epilepsy, Temporal Lobe, female, male, nerve cell, temporal lobectomy, Anterior Temporal Lobectomy, Humans, Matrix Metalloproteinase 2, Matrix Metalloproteinase 9, Neurons, Tissue Inhibitor of Metalloproteinase-1, Tissue Inhibitor of Metalloproteinase-2 |
| الوصف: | Aim: The molecular mechanism of epileptogenesis in temporal lobe epilepsy is still unclear. Experimental studies have suggested that matrix metalloproteinases have important roles in this process, but human studies are limited. The aim of this study was to assess the expression of MMP-9, MMP-2 and their tissue inhibitors (TIMP-1 and TIMP-2) in patients with temporal lobe epilepsy with hippocampal sclerosis (TLE-HS). Material and Methods: The tissue samples from temporal neocortex and hippocampus were obtained from patients with temporal lobe epilepsy with hippocampal sclerosis who had undergone anterior temporal lobectomy for recurrent medically resistant seizures. Immunohistochemical methods were used to determine the expression of MMP-9, MMP-2 and their tissue inhibitors. Tissue samples were also analyzed with transmission electron microscopy. Results: The immunoreactivity for MMP-9 both in hippocampal and temporal neocortical neurons was stronger than that of MMP-2. Additionally, there was a mild reaction for its tissue inhibitor TIMP-1 as with TIMP-2. The TEM analysis of the hippocampus revealed that there was apparent ultra-structural damage on the pericarya and neuropil of some neurons. There was obvious damage in the mitochondria and the nuclear membrane. Conclusion: The preliminary results of this study revealed that MMP-9 may have a role in patients with drug resistant TLE-HS. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1019-5149 |
| العلاقة: | Turkish Neurosurgery; Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı; https://hdl.handle.net/11499/10345Test; https://doi.org/10.5137/1019-5149.JTN.10738-14.0Test; 25; 749; 756; 2-s2.0-84944612860; WOS:000374071900012 |
| DOI: | 10.5137/1019-5149.JTN.10738-14.0 |
| الإتاحة: | https://doi.org/10.5137/1019-5149.JTN.10738-14.0Test https://hdl.handle.net/11499/10345Test |
| حقوق: | open |
| رقم الانضمام: | edsbas.FD2AE642 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 10195149 |
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| DOI: | 10.5137/1019-5149.JTN.10738-14.0 |